EDEM1

EDEM1

A gene on chromosome 3p26.1 that encodes an enzyme directly involved in endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It interacts with DERL2 and DERL3.
References in periodicals archive ?
Expression of XBP1 and EDEM1 suggested induction of ERAD pathway, which in turn stimulates ER chaperones.
When HeLa cells were subjected to ER stress for 14, 24 and 42 h, most of the chaperones, including CNX, calreticulin, BiP, EDEM1, FBG3, ERGIC-53, MCFD2, and VIP36, were increased by more than 5-fold 24 h after the induction of ER stress.
When trimming of an outermost Man residue occurs on the C-arm of high mannose-type glycans by EDEM1 or EDEM3, it binds OS-9 and XTP3-B.
EDEM1 is one of the ER stress markers that strongly correlate with total adiposity.