The EDA, EDAR and EDARADD genes provide instructions for making proteins that work together during embryonic development.
Autosomal forms of HED are due to mutation in the EDA receptor (EDAR) and EDAR associated death domain (EDARADD).
HED is the most frequent form, caused mainly by mutations in the EDA gene, located at the long arm of the X-chromosome (Xq12-q13.1), followed by the EDAR and EDARADD
Descriptions of the five widely adopted genes--ASPA, EDARADD, FHL2,
The EDARADD gene (EDAR associated death domain) is located on
A total of 21 CpG sites related to EDARADD are included in HM450, from
The dispersion diagrams for EDARADD in Figure 1C indicate that a loss of
(ASPA, PDE4C, ELOVL2, and EDARADD), and subsequently was tested on
To predict the age of a per son based on a biological sample, a multivariate linear regression was built based on the methylation of only two cytosines (Edar-associated death domain (Edaradd
) and neuronal pen traxin II (NPTX2) genes), that covered 73% of the variance in age, with an average accuracy of 5.2 years.
Dahl, "Isolated oligodontia associated with mutations in EDARADD
, AXIN2, MSX1, and PAX9 genes," American Journal of Medical Genetics Part A, vol.
Mutations in the gene Ectodysplasin-A receptor (EDAR) and Ectodysplasin-A Receptor-Associated Adapter (EDARADD
) are also responsible for the rare autosomal dominant and autosomal recessive forms [9, 10].