The authors showed that oxytocin ED90
in these patients was 0.29 IU min, which is equivalent to diluting 15 IU of oxytocin in 1 L saline and infuse this solution in 1 h.
Though limited data are available on the use of intrathecal hydromorphone for acute postoperative pain, a recent prospective comparison of spinal hydromorphone and morphine in cesarean section determined that the ED90 of intrathecal hydromorphone was 75mcg .
Jacob et al., "Intrathecal hydromorphone and morphine for postcesarean delivery analgesia: determination of the ED90 using a sequential allocation biased-coin method," Anesthesia and Analgesia, vol.
(9) Office of the Attorney General, http://myfloridalegal.com/pages.nsf/ Main/42F7E9863E852570AB0059 ED90
It has been determined that the ED90
effect for uterine myocyte stimulation (the dose that can be expected to confer 90% maximal contraction) is 0.35 IU in oxytocin-naive patients at CS and 3.0 IU in patients who have previously been augmented with oxytocin during labour.
Up-down determination of the ED90
of oxytocin infusions for the prevention of postpartum uterine atony in parturients undergoing cesarean delivery.
From the ED50 and the Hill slope the ED90
values were calculated using the formula LogED50 = LogED90 (1/Hill Slope) x log(9) and the equation Y = Bottom + (Top - Bottom)/(1 + 10 [and] ((LogED50-X) x Hill slope)) .
Kim and colleagues' data, admittedly from a cohort of 108 Korean patients, predicted an ED90
dose for successful block (i.e.
(6) the minimum effective bolus dose for 90% of patients (ED90
) at elective Caesarean section has recently been estimated to be as low as 0.35 u.
In this prospective, randomised, double-blind, dose-response study we undertook to determine whether the duration of anaesthesia differed between the obese and non-obese patient, and to compare the median effective dose (ED50) and 90% effective dose (ED90
) of intrathecal hyperbaric bupivacaine in obese and non-obese patients, using probit regression analysis.
Vecuronium may be superior to other non-depolarizing muscle relaxants for rapid-sequence induction because of its relatively short onset and duration of action and its lack of cardiovascular side effects even at doses upto 12 times the ED90