ED50


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Related to ED50: therapeutic index, TD50

dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

ED50

Abbreviation for median effective dose.

ED50

median effective dose.

ED50

ED50

Abbreviation for median effective dose.

ED50

Abbreviation for median effective dose.

ED50,

ED50

median effective dose.
References in periodicals archive ?
Por tanto, para obtener altitud elipsoidal en ED50 es siempre imprescindible disponer de valores de ondulacion en este sistema local que se obtienen de un modelo de geoide (geocentrico) mediante un proceso iterativo que parte de considerar N=0, o valor conocido, en el punto origen (Datum) o bien con 5/7 parametros de transformacion a priori.
In addition the ED50 values of propanil quinclorac and cyhalofop-butyl for the R biotype were well above the recommended rates.
In the present study the ED50 of intrathecal hyperbaric bupivacaine for successful anaesthesia and the highest levels of sensory and motor blocks did not differ between the two patient cohorts, although time to first request for supplemental analgesia and first self-voiding were significantly prolonged in obese patients.
ED50 values of barnyardgrass treated with pretilachlor, thiobencarb and sunflower leaf extracts alone were reduced drastically by 2 to 30-fold when sunflower leaf extracts were mixed with thiobencarb or pretilachlor at all ratios except at a combination of 90 (Percent) herbicides and 10 (Percent) sunflower leaf extracts that exhibited antagonistic activity (Table 2 and 3).
50] of ARG was significantly reduced by BSO pre-treatment in A549 lung cancer cells and OUMS-36T-2F normal cells, whereas no changes in ED50 were observed in OUMS-36 and OUMS-36T-5F normal cells (Fig.
Specifically, the new ALN-PCSsc drug candidate demonstrated potent knockdown of the PCSK9 target gene with an ED50 <0.
Table 1 shows that Radix rhodiola extract RR increased the swimming time of rats in a dose dependent manner, ED50 = 7 mg/kg.
Pre-clinical data from the ALN-PCS program have shown specific silencing of PCSK9 messenger RNA (mRNA) in the liver, and plasma PCSK9 protein levels of up to 90%, with an ED50 (the dose that provides a 50% silencing effect) of approximately 0.
Furthermore, this global difference can be explained in large part by a combination of differences in ED50 and maximal response of the curves (F = 5.
These data demonstrate dose-dependent silencing of protein C mRNA with silencing of greater than 90% and an ED50 of approximately 0.
At the 7th Annual Meeting of the Oligonucleotides Therapeutics Society in September 2011, Alnylam presented pre-clinical data from its ALN-APC program showing dose-dependent silencing of the protein C mRNA with an ED50 of 0.