ED50


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Related to ED50: therapeutic index, TD50

dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ED50

Abbreviation for median effective dose.
Farlex Partner Medical Dictionary © Farlex 2012

ED50

Abbreviation for median effective dose.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

ED50

Abbreviation for median effective dose.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
(20) Nevertheless, the reported LD50 (0.93 mL/kg) and ED50 (0.52 mL/kg) of anise oil in mice (31) indicate that this oil has a low therapeutic index (1.79) and that its reported anticonvulsant doses in mice are within a toxic range.
2004 [28] show that the ED50 threshold for 3 us 590 nm pulses varies with retinal spot size.
ED50 and ED95 of intrathecal hyperbaric bupivacaine coad-ministered with opioids for cesarean delivery.
Choice of number of doses for maximum likelihood estimation of the ED50 for quantal dose-response data.
Some (e.g., Finney 1978; Tsutakawa 1980) have approached it with the goal of most precisely estimating a particular percentile of the logistic curve, such as the median (or ED50, as it is called in dose-reponse studies).
The effective dose 50 (ED50) value; the dose for which 50% of animals fail to climb backward out of the tube within 30 s was calculated by log-probit analysis.
Comparison of the ED50 values of AZE and haloperidol revealed that HAL was more potent than AZE (Table 1).
The 95% effective dose (ED95) was 1.2 [+ or -] 0.52 mg rtPA; the 50% effective dose (ED50) was 0.6 [+ or -] 0.1 mg (Figure 4(a)) [21,22].
Compared to concurrent controls, a significant anti-nociceptive activity was observed in methanol extract LC (ED50 50 mg/kg, P < 0.002) and its sub-fractions LCEA-AQ (ED50 50 mg/kg, P < 0.004), LCEA (ED50 100 mg/kg, P < 0.004) and LCEA-PEI (ED50 100 mg/kg, P two times the pre-drug average latency.
Muzi's dosages were selected because of a previous study by Ben-Shlomo et al (12) (1990) showing that Fentanyl and Midazolam act synergistically and that 25% of the ED50 of Fentanyl was required in combination with 23% of the ED50 for Midazolam to achieve the ED50 of the combination.