ECASS


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ECASS

Cardiology An international, double blinded, randomized trial–European Cooperative Acute Stroke Study which evaluated effects of thrombolytics in Pts with stroke. See Thrombolytic therapy, tPA.
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Manfred Haehl, Corporate Senior Vice President Medicine, Boehringer Ingelheim said: "We are proud of the success of ECASS 3 and would like to thank our lead investigator, all the investigators throughout Europe, the trial team and most notably patients and their relatives for their participation in this landmark study in acute ischaemic stroke.
ECASS 3 was a randomised, double-blind, multicentre, placebo-controlled trial of Actilyse(R) in acute ischaemic stroke where thrombolysis is initiated between 3 and 4.
However, the new ECASS 3 data show that stroke can be effectively managed also in patients who are unable to reach a stroke centre within three hours," commented Professor Werner Hacke, Department of Neurology, Ruprecht-Karls-University of Heidelberg, Germany, lead study investigator.
However, the authors note that intravenous tissue plasminogen activator (tPA) 'is an accepted therapy' and 'significantly improves outcome'; particular reference is made to the ECASS III trial (2) to justify its use within 4.
To date, L-3 has configured the ECASS for multiple durability tests, the most recent of which was performed in the spring of 2009.