ECASS


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ECASS

Cardiology An international, double blinded, randomized trial–European Cooperative Acute Stroke Study which evaluated effects of thrombolytics in Pts with stroke. See Thrombolytic therapy, tPA.
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In NINDS, ATLANTIS, ECASS II, ECASS III, and EPITHET, patients in the alteplase group were assigned to receive a total intravenous dose of 0*9 mg/kg bodyweight (90 mg maximum) whereas in ECASS I the total dose was 1*1 mg/kg (100 mg maximum).
ECASS 3 demonstrated that Actilyse[R] can increase favourable outcomes with only minimal or no disability after 90 days versus placebo, following an acute ischaemic stroke when administered in an extended time-window from 3 to 4.
ECASS II is a placebo controlled randomized trial of acute ischemic stroke patients presenting within 0-6 hours of symptom onset.