SOD3

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SOD3

A gene on chromosome 4p15.3-p15.1 that encodes an extracellular superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress.
References in periodicals archive ?
Folz, "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), MnSOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology and Medicine, vol.
The EC-SOD is a glycoprotein with a molecular weight of 135,000 kDa with high affinity for heparin.
Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression.
The researchers then looked at the various forms of the EC-SOD gene in two groups of patients with infection-associated ALI.
Although We are not yet sure how these particular SNPs alter the action of the EC-SOD, these findings gives us a good starting point to learn more about possible protective mechanisms in ALI and other lung diseases," he added.
EC-SOD is a naturally occurring enzyme that has been shown to reduce damage resulting from free-radical formation in ischemic and traumatic-brain-injury models.
This work is unique because EC-SOD is almost exclusively located in the extracellular environment and thus allows examination of the role of extracellular ROS in SCI.
Folz, "Superoxide dismutase multigene family: a comparison ofthe CuZn-SOD (SOD1), MnSOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology and Medicine, vol.
Adachi, "Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells," Free Radical Research, vol.
Folz, "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology and Medicine, vol.
Intramuscular injection of liposomal CuZn-SOD, intra-tracheal injections of Mn-SOD plasmid-liposome or Mn-SOD adenovirus gene therapy, and overexpression of EC-SOD in transgenic mice prior to irradiation were effective in attenuating radiation damage [10, 14, 29-31] which further indicated the importance of intracellular delivery of SOD for the radioprotective effect.