SOD3

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SOD3

A gene on chromosome 4p15.3-p15.1 that encodes an extracellular superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress.
References in periodicals archive ?
Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression.
Similar to the role of EC-SOD in the rat bleomycin model of BPD and PH inhibition of tissue necrosis factor (TNF-[alpha]) signaling by both pharmaceutical intervention and exposure to 7% C[O.sub.2] caused reduced PH symptoms and reduced lung injury, indicating a role of TNF-[alpha] signaling in disease development [68].
Tang et al., "Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension," Pediatric Research, vol.
Folz, "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), MnSOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology and Medicine, vol.
During the study, the researchers looked at the gene for extracellular superoxide dismutase (EC-SOD), a powerful antioxidant that has been associated with reduced lung injury in animal models, and better patient outcomes in chronic obstructive pulmonary disease.
The researchers then looked at the various forms of the EC-SOD gene in two groups of patients with infection-associated ALI.
This project will examine the effect of extracellular superoxide dismutase (EC-SOD) in a model of spinal-cord compression injury such as could occur with trauma or compromise of the spinal canal by a tumor or blood clot.
This work is unique because EC-SOD is almost exclusively located in the extracellular environment and thus allows examination of the role of extracellular ROS in SCI.
Extracellular superoxide dismutase (EC-SOD, SOD3) [1, 2], similar to cytosolic CuZn-SOD (SOD1) [3] and mitochondrial MnSOD (SOD2) [4, 5], catalyzes the dismutation of superoxide anion ([O.sub.2.sup.-]) into hydrogen peroxide ([H.sub.2][O.sub.2]) (in this review reactive oxygen species refer to [O.sub.2.sup.-] and [H.sub.2][O.sub.2]), which to date is the only reported physiological function of the enzyme.
Sjoquist, "Extracellular-superoxide dismutase type C (EC-SOD C) reduces myocardial damage in rats subjected to coronary occlusion and 24 hours of reperfusion," Free Radical Research Communications, vol.
Folz, "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology and Medicine, vol.