EB simplex

EB simplex

; Weber-Cockayne EB non-scarring blistering at basal layer of epidermis, often affecting palmar/plantar or other areas of easily traumatized skin, and worse in summer weather
  • dystrophic EB severe scar-inducing blistering at lower levels of dermoepidermal junction; onset during infancy, with a relentlessly progressive course causing marked scarring in response to minor trauma, fusion and resorption of fingers and toes, growth retardation, anaemia and oesophageal strictures

  • junctional EB scar-inducing blistering at upper levels of dermoepidermal junction

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4 Recent classification depends on the level of tissue cleavage following trauma5, there are three major subtypes; EB simplex where cleavage is intraepidermal, it appears at birth with bullae formation limited to hands and feet that heal without scaring6, dystrophic EB where splitting is at sub lamina densa with bullae formation on feet, ankles, elbows and hands with absent or dystrophic nails and oral lesions that healed with scars, junctional EB the cleavage at lamina lucida , lesions appear at birth bullae and erosions formed which healed with scars on hands and feet with dystrophic nails and oral lesions.
The less severe EB simplex form was present in 11 patients; 8 had the most severe junctional form.
This suggested the benign nature of disease as mostly is seen in cases of EB simplex and was also the reason of our tendency to associate it with EB simplex.
Localized EB simplex, Weber-Cockayne subtype, can present in adulthood.
There are four major type of inherited epidermolysis bullosa: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB) and Kindler syndrome.
Treatment can include simple things like avoiding triggering factors such as walking for long distances in warm weather, which causes blistering on the soles of the feet in EB Simplex.
Two out of three sufferers have EB simplex, which affects hands and feet.
Two of the new reports focus on EB simplex, blaming it on a genetic defect in keratin -- the key protein in the springy "inner skeletons" of cells.
The ultra-structural level of tissue cleavage (blister formation) in the skin is distinctive in the three major groups of EB: EB simplex, junctional EB and dystrophic EB.
At least 27 different types of EB have been described, but the three main forms are EB simplex, Dystrophic EB and Junctional EB.
Tony has a form of EB simplex known as Dowling-Meara, which varies in severity.
EB can be divided into three main types ( EB simplex, junctional EB and dystrophic EB.