SLC1A1

(redirected from EAAT3)

SLC1A1

A gene on chromosome 9p24 that encodes solute carrier family 1 member 1, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters terminate the postsynaptic action of the neurotransmitter glutamate and maintain extracellular glutamate concentrations below neurotoxic levels. SLC1A1 also transports aspartate.

Molecular biology
SLC1A1 loss-of-function mutations cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
However, the dietary CP levels did not influence expression of the neutral AAT ASCT1 and acidic AAT EAAT3 in the colon (Fig.
Reducing protein concentration in dietary will not affect the ASCT1 and EAAT3 expression, which implied low protein could also guarantee amino acid absorption.
Villaescusa et al., "MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro," International Journal of Neuropsychopharmacology, vol.
The immunocontent of GLAST, GLT1, EAAT3, and glyoxalase 1 was determined for optical density.
Importantly, decrease glutamate uptake in astrocytes was not associated with changes in the contents of GLAST (Figure 5(c)), GLT-1 (Figure 5(e)), or EAAT3 (Figure 5(g)), as determined by Western blotting.
Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR.
Zaragoza et al., "[Na.sup.+] dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress," Brain Research, vol.
Esta familia de proteinas incluye cinco miembros: GLAST (tambien conocido como EAAT 1), transportador glial encontrado sobre todo en el cerebelo; GLT 1 (o EAAT2), el principal transportador glial del telencefalo, EAAC1 (o EAAT3), transportador neuronal tambien de localizacion en el telencefalo, EAAT 4, transportador neuronal del cerebelo y el transportador EAAT 5, un transportador neuronal-glial presente en la Retina (14).
The invention is directed toward the isolation, characterization and pharmacological use of the human amino acid transporter proteins EAAT1, EAAT2, EAAT3 and ASCT1.
recently showed that NRG-1 promotes neuronal EAAT3 expression, particularly in parvalbumin-expressing GABAergic interneurons [15].
Thus in neurons roughly 90% of cysteine uptake is provided by the EAAT3 transporter [26].
Cysteine uptake in SH-SY5Y is primarily mediated by excitatory amino acid transporter 3 (EAAT3) [18], and the ability of mercury to inhibit EAAT3 in primary neurons has been previously reported [19].