excitatory amino acid transporter

(redirected from EAAT)
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excitatory amino acid transporter

Any of the sodium- and potassium-dependent members of the solute carrier family (SLC) 6, which are widely distributed in the brain. EAATs regulate excitatory neurotransmission, maintain low extracellular glutamate concentrations (reducing neurotoxicity) and provide glutamate for glutamate-glutamine cycle metabolism. Each of the five subtypes has a main primary distribution:
• EAAT1—Cerebellar glia;
• EAAT2—Forebrain glia;
• EAAT3—Cortical neurons;
• EAAT4—Cerebellar Purkinje neurons;
• EAAT5—Retina.

Molecular pathology
EAAT overactivity has been implicated in schizophrenia and other mental illnesses; underactivity occurs in ischaemia and traumatic brain injury.
References in periodicals archive ?
Those future EAAT studies got a boost in March from PATH, when it announced an additional space on its social networking site, Community Connections, for researchers to connect with each other.
It's hoped that more research on EAAT will help create and expand additional programs so more individuals who may benefit from this therapy will have the opportunity to get in the saddle.
1 and 2 together, the effect of degree of neutralization of the EAAT modifier on tensile and impact behavior of POM blends can be rationalized as follows.
The evolution of the storage modulus (G[prime]) and loss tangent [Delta] (tan [Delta]) for the homopolymers and the 80/20 blends of EAAT and EAAT-Zn-25 are shown in Figs.
where Tg is the glass transition temperature of the EAAT rich phase, [Tg.
giving the amount of POM content in the EAAT rich phase.
However, it is noted that the decrease in the Tg of the EAAT-Zn 25 rich phase is more pronounced than for the EAAT containing blends (Table 2).
Bigger particles are clearly visible in the EAAT containing blends reflecting a poor adhesion between components due to their surface tension.
Brandy's story and other participants' accounts reinforce the benefits of complementing traditional cognitive rehabilitation with EAAT to remediate the devastating long-term effects of TBI.