SLC1A1

(redirected from EAAC1)
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SLC1A1

A gene on chromosome 9p24 that encodes solute carrier family 1 member 1, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters terminate the postsynaptic action of the neurotransmitter glutamate and maintain extracellular glutamate concentrations below neurotoxic levels. SLC1A1 also transports aspartate.

Molecular biology
SLC1A1 loss-of-function mutations cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.
References in periodicals archive ?
Posterior a isquemia focal transitoria, se ha descrito que los niveles de proteinas y de la expresion del RNAm para GLT1 y EAAC1 disminuyen significativamente (entre 36% y 56%) en el hemisferio isquemico al compararlo con la corteza contra-lateral o con los especimenes control (16).
Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain.
Kiyama, "Unique anti-apoptotic activity of EAAC1 in injured motor neurons," The EMBO Journal, vol.