SLC1A1

(redirected from EAAC1)
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SLC1A1

A gene on chromosome 9p24 that encodes solute carrier family 1 member 1, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters terminate the postsynaptic action of the neurotransmitter glutamate and maintain extracellular glutamate concentrations below neurotoxic levels. SLC1A1 also transports aspartate.

Molecular biology
SLC1A1 loss-of-function mutations cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.
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References in periodicals archive ?
Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain.
We previously reported that spermidine prevents RGC death and visual impairment following ONI and in EAAC1 KO mice, by reducing oxidative stress levels in the retina (Figure 1) [20, 59].
Indeed, we reported that suppression of the renin-angiotensin system by candesartan led to RGC protection and preservation of visual function in EAAC1 KO mice [17], suggesting that this drug may be a good drug repurposing candidate for glaucoma therapy.
Caption: Figure 1: Spermidine reduces oxidative stress levels in the EAAC1 KO mouse retina.
Nam et al., "Neuregulin 1 controls glutamate uptake by up-regulating excitatory amino acid carrier 1 (EAAC1)," The Journal of Biological Chemistry, vol.
Besides these results on the NMDAr, one study suggests that A[beta] can also reduce the glutamate reuptake (by inactivation of the EAAC1 transporter), thus increasing the extracellular concentration of glutamate and promoting a receptor desensitization, which would improve the LTD and inhibit the LTP [47].