RAD18(redirected from E3 ubiquitin-protein ligase RAD18)
RAD18A gene on chromosome 3p25-p24 that is highly similar to the Saccharomyces cerevisiae DNA damage repair protein Rad18; it interacts with the human homologue of the yeast Rad6 protein via a conserved RING finger motif.
Mutation of the RING finger motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
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