STUB1

(redirected from E3 ubiquitin-protein ligase CHIP)

STUB1

A gene on chromosome 16p13.3 that encodes a ubiquitin ligase/co-chaperone, which participates in protein quality control by targeting various chaperone protein substrates (e.g., misfolded chaparones for proteosomal degradation) and modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.