RANBP2(redirected from E3 SUMO-protein ligase RanBP2)
RANBP2A gene on chromosome 2q12.3 that encodes a very large RAN-binding protein that immunolocalises to the nuclear pore complex. It is a scaffold and mosaic cyclophilin-related nucleoporin involved in the Ran-GTPase cycle; it interacts directly with the E2 enzyme UBC9 and enhances the transfer of SUMO1 (sumoylation) to its target SP100. RANBP2 is partially duplicated in a gene cluster that lies in the chromosome 2 recombination hot spot.
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