The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7
The main molecular targets for gga-miR-302b-3p were MAP3K14, E2F7
, LATS2, TRPS1, CDK6, RAPGEF2, and TGFfiR2.
The expression of WNT5A, Kit ligand (KITGL), FGF5, E2F transcription factor 7 (E2F7), and ETS protooncogene 1 transcription factor (ETS1) was significantly increased from day 4 compared to day 0 (mature adipocytes) and from day 12 compared to day 7.
We report an increase in gene expression of WNT5A and E2F7 in both the early and the late stages of dedifferentiation.
Among miRNA-16-downregulated targets are many known cell cycle regulators that did not induce G0/G1 cell accumulation but may modify the effects of other targets (i.e., E2F7
, CDC25A, CHEK1, WEE1, and CCNE1 genes) .
The genes E2F7
and IL-11RA were then identified as potential toxicity biomarkers for acetaminophen treatment.