By contrast, the transcription repressor subfamily member E2F4 was able to inhibit transcription of proapoptotic genes E2F1 and Apaf-1 and antagonize hypoxia-induced cardiomyocyte death [240].
von Harsdorf, "Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes," Journal of Molecular and Cellular Cardiology, vol.
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
(326,327) Accumulation of MSI in growth regulatory and tumor suppressor genes, such as the Bloom syndrome helicase gene, the proapoptotic BAX gene, PTEN, and the
E2F4 transcription factor involved in cell cycle control, is then thought to drive tumorigenesis.
Dingar and colleagues utilized chromatin immunoprecipitation to determine that the E2F transcription factor 4 (E2F4)-p130-repressor directly blocks transcription of essential apoptosis-related genes, E2F1, Apaf-1, and p73a, through recruitment of HDAC1 causing apoptosis.
Zou et al., "Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes," Journal of Molecular and Cellular Cardiology, vol.
E2F4, as well as ZNF207, was activated within the deterioration of AD.
ENO1 was regulated by ZNF207, BUB3, PTBP1, E2F4, POLR2E, and STIP1.
Expression of several genes appeared to be down regulated, including FOXM1 , thought to be a direct target of hedgehog signaling; K167, function unkown; and Retinoblastoma (RB), E2F2, and
E2F4. RB and
E2F4 have been shown necessary for erythroid maturation in knockout mice, suggesting a partial mechanism for the cyclopamine-induced delay of erythroid maturation.