A total of 4 genes (PIK3CA, CDKN1B, KRAS, and E2F3
) existed in All Sources and Lymphocyte Source sets, simultaneously.
XIST induced the upregulation of E2F3
(E2F transcription factor 3), which is a critical protein for tumor cell proliferation.
For instance, NETA1 functioned as a ceRNA for miR-377-3p, antagonized its function, and led to the derepression of its endogenous target E2F3
, which was a core oncogene in promoting non-small-cell lung carcinoma progression .
Quentmeier et al., "HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3
," Leukemia, vol.
It included genes for apoptosis (Tp53, TP53INP2, and DFFA), antiapoptosis (BCL2), cell proliferation (E2F3
and Ki67), and cell differentiation (SOX2) (Figure 2).
Zhang et al., "MicroRNA-432 functions as a tumor suppressor gene through targeting E2F3
and AXL in lung adenocarcinoma," Oncotarget, vol.
In HCC, miR-195 inhibited the cell cycle by downregulating cell cycle protein D, the transcription factor E2F3
, and cyclin-dependent kinase 6 [18-20].
MiR-125b-5p is upregulated in many cancers but downregulated in others, such as breast cancer, and controls many different cellular processes by targeting numerous transcription factors such as ETS1, E2F3
, and BCL3 (23-25).
E2F family members, such as E2F1, E2F2, and E2F3
, are critical for engaging the cell cycle by upregulating expression of key genes such as Cyclin E, Cyclin A, and Cyclin B .
Exploration of potential ligands against cancer-causing transcription factor E2F3
. Pakistan J.
(25) Those data are not conflicting with ours because miR-125b targets many different genes, such as E2F3
in breast cancer cells.