E2F3

E2F3

A gene on chromosome 6p22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F3 binds specifically to the tumour suppressor retinoblastoma protein pRB in a cell-cycle-dependent manner.
References in periodicals archive ?
MiR-125b-5p is upregulated in many cancers but downregulated in others, such as breast cancer, and controls many different cellular processes by targeting numerous transcription factors such as ETS1, E2F3, and BCL3 (23-25).
MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.
Exploration of potential ligands against cancer-causing transcription factor E2F3.
25) Those data are not conflicting with ours because miR-125b targets many different genes, such as E2F3 in breast cancer cells.
Lakshman Varanassi, UMMC E2F3 and the DNA damage response: How genomics enables discovery 2.
On the other hand, the non-ischemic wounds on the mice showed abundant levels of the E2F3 protein and healed normally within about seven days.
The test, which can be carried out on prostate cancer biopsies, looks for various genes associated with the disease including the E2F3 gene.
The Checkerboard Tissue Microarray (TMA) Method, developed by scientists at the Institute of Cancer Research, looks for the multiple markers of various genes associated with prostate cancer - including the E2F3 gene.
They found there was an over- expression of E2F3 in the cancer cells and that the more E2F3 was present, the worse the prognosis was for the patient.
Additionally, they noted that the amount of E2F3 proteins present was a significant indicator of the seriousness of the cancer.
Triptolide downregulated the cell cycle-related genes E2F2 E2F3, E2F5, CDKN2C, CDK7, CDC23, and SMAD3; the MAPK signaling pathway genes FOS, CASP3, JUND, KRAS, MAP2K2; and the Wnt signaling pathway genes WNT4, MYC, and AXIN2.
The newly-identified gene, E2F3, produces a protein which plays a key role in promoting cell division in all human cells.