E2F2

E2F2

A gene on chromosome 1p36 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F2 binds specifically to the tumour suppressor retinoblastoma protein pRB in a cell-cycle-dependent manner.
References in periodicals archive ?
Within the top differentially methylated CpG sites in the overall population, several genes related to protein regulation and function were present (e.g., CSNK1E, E2F2, PSMB8, PPP1R12B, and PDK1).
For instance, miR-155-5p targets E2F2 transcription factor to enhance the angiogenic capability of induced endothelial cells [16].
El factor de crecimiento E2F1, sus homologos E2F2 y E2F3, as como otros procesos que no se describen aqu (por ejemplo, las ciclinas y cinasas dependientes del ciclo) forman un sistema estrechamente regulado por la division celular.
Zubiaga, "E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution," Cell Death and Differentiation, vol.
Cell-cycle arrest in the senescent state results from alteration of markers associated with the cell cycle, including cell-cycle inhibitors (p53, p21, p16, and pRb) and cell-cycle activators (E2F1 and E2F2) [5].
Likewise, recent study has demonstrated the tumor-suppressor activity of miRNA-214 by inhibiting CDK6, CDK3, and E2F2 [149].
E2F2, a member of E2F transcription factor family, was identified as the target gene of hsa-miR-1915 and hsa-miR-2861.
Modeling time-dependent transcription effects of HER2 oncogene and discovery of a role for E2F2 in breast cancer cell-matrix adhesion, Bioinformatics 30(21): 3036-3043.
E2F family members, such as E2F1, E2F2, and E2F3, are critical for engaging the cell cycle by upregulating expression of key genes such as Cyclin E, Cyclin A, and Cyclin B [49].
Excessive formation of cyclin E-CDK2 complexes induced high expression of the E2F family such as E2F1 and E2F2, resulting in further p53 activation.
UBE2E2, Ubiquitin conjugating enzyme E2F2 (3) BCL11A, B/cell lymphoma/leukemia Encodes C2H2 type zinc-finger 11A (2) protein.