Within the top differentially methylated CpG sites in the overall population, several genes related to protein regulation and function were present (e.g., CSNK1E, E2F2
, PSMB8, PPP1R12B, and PDK1).
For instance, miR-155-5p targets E2F2
transcription factor to enhance the angiogenic capability of induced endothelial cells .
Zubiaga, "E2F1 and E2F2
prevent replicative stress and subsequent p53-dependent organ involution," Cell Death and Differentiation, vol.
Cell-cycle arrest in the senescent state results from alteration of markers associated with the cell cycle, including cell-cycle inhibitors (p53, p21, p16, and pRb) and cell-cycle activators (E2F1 and E2F2
Likewise, recent study has demonstrated the tumor-suppressor activity of miRNA-214 by inhibiting CDK6, CDK3, and E2F2
, a member of E2F transcription factor family, was identified as the target gene of hsa-miR-1915 and hsa-miR-2861.
Modeling time-dependent transcription effects of HER2 oncogene and discovery of a role for E2F2
in breast cancer cell-matrix adhesion, Bioinformatics 30(21): 3036-3043.
E2F family members, such as E2F1, E2F2
, and E2F3, are critical for engaging the cell cycle by upregulating expression of key genes such as Cyclin E, Cyclin A, and Cyclin B .
O teste de generalizacao 1 avaliou as relacoes E1F1, E2F2
, E3F3, F1E1, F2E2 e F3E3.
Excessive formation of cyclin E-CDK2 complexes induced high expression of the E2F family such as E2F1 and E2F2
, resulting in further p53 activation.
UBE2E2, Ubiquitin conjugating enzyme E2F2
(3) BCL11A, B/cell lymphoma/leukemia Encodes C2H2 type zinc-finger 11A (2) protein.