Also, significant upregulation of p21 and E2F1
, both predicted miR-17 target mRNAs, was found in natalizumab treated patients (3.3-fold for p21 and 1.3-fold for E2F1
) (Figure 3(a), bottom panels).
miRNA-331-3p directly targets E2F1
and induces growth arrest in human gastric cancer.
and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination.
Expression of transcription factor E2F1
induces quiescent cells to enter S phase.
The probe set IDs of TaqMan probe and primer sets for ACLY, AURKB, CD74, CDKN2D, E2F1
, EFEMP1, LIF, and TGM2 are provided in Table 1.
It binds to and inactivates the E2F1
transcription factor, which is essential for cell cycle progression [103-105].
Moran, "Cooperative activation of tissue-specific genes by pRB and E2F1
," Cancer Research, vol.
Enrichment of E2F1
in acetylated H3K9 promoters of TP53, BAX, PUMA, C-MYC, and C-FOS fragment precipitation was detected with antiacetylated H3K9 and anti-E2F1 antibodies.
Rb remains associated with transcription factor E2F1
localizing it to the cytoplasm and thus preventing transcription of E2F1
target genes that, as mentioned above, are crucial for the G1/S transition .
Cyclin D1 and c-myc are two classic target genes of wnt/[beta]-catenin signaling which are related to proliferation , cyclin D1 overexpression in PDAC correlates with poor postoperative patient survival , and c-myc protein expression is connected to the transcription of the E2F1
gene in PDAC cells, leading to S-phase progression of the cell cycle .
and E2F2 prevent replicative stress and subsequent p53-dependent organ involution," Cell Death and Differentiation, vol.
Yao et al., "Transactivation of microRNA320 by microRNA-383 regulates granulosa cell functions by targeting E2F1
and SF-1 proteins," Journal of Biological Chemistry, vol.