E2F1

E2F1

A gene on chromosome 20q11.2 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2Fs are targets of transforming proteins of small DNA tumour viruses.
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Also, significant upregulation of p21 and E2F1, both predicted miR-17 target mRNAs, was found in natalizumab treated patients (3.3-fold for p21 and 1.3-fold for E2F1) (Figure 3(a), bottom panels).
miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer.
The probe set IDs of TaqMan probe and primer sets for ACLY, AURKB, CD74, CDKN2D, E2F1, EFEMP1, LIF, and TGM2 are provided in Table 1.
It binds to and inactivates the E2F1 transcription factor, which is essential for cell cycle progression [103-105].
Moran, "Cooperative activation of tissue-specific genes by pRB and E2F1," Cancer Research, vol.
Enrichment of E2F1 in acetylated H3K9 promoters of TP53, BAX, PUMA, C-MYC, and C-FOS fragment precipitation was detected with antiacetylated H3K9 and anti-E2F1 antibodies.
Rb remains associated with transcription factor E2F1 localizing it to the cytoplasm and thus preventing transcription of E2F1 target genes that, as mentioned above, are crucial for the G1/S transition [20].
Cyclin D1 and c-myc are two classic target genes of wnt/[beta]-catenin signaling which are related to proliferation [19], cyclin D1 overexpression in PDAC correlates with poor postoperative patient survival [30], and c-myc protein expression is connected to the transcription of the E2F1 gene in PDAC cells, leading to S-phase progression of the cell cycle [34].
Zubiaga, "E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution," Cell Death and Differentiation, vol.
Yao et al., "Transactivation of microRNA320 by microRNA-383 regulates granulosa cell functions by targeting E2F1 and SF-1 proteins," Journal of Biological Chemistry, vol.