E2F4

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E2F4

A gene on chromosome 16q21-q22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F4 binds to tumour suppressor proteins p107 and p130, and also (though with less affinity) to retinoblastoma protein pRB.
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References in periodicals archive ?
As for the Aurora-A promoter, also the Aurora-B promoter possesses the CDE and CHR elements, though responsible for the cell cycle regulation of its expression, and several CDE-binding proteins have been identified by means of electrophoretic mobility shift assay and biotinstreptavidin pull-down assay, including the E2F-1, E2F-4, and DP-2 [23].
In addition, microsatellite mutations in the IGF2R gene and transcription factor E2F-4 gene have also been detected.
Cobrinik et al., "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle," Proceedings of the National Academy of Sciences of the United States of America, vol.