TQ inhibited DNA synthesis, proliferation, and viability of cancerous prostate epithelial cells by down-regulating androgen receptors and E2F-1
, a regulator of cell proliferation and viability, without affecting the noncancerous cells (34), inhibited benzo(a)pyrene (BP)induced forestomach carcinogenesis (35), prevented MCA-induced fibrosarcoma tumours (36), and blocked tumour angiogenesis in a xenograft human prostate cancer in mice (37).
In addition, CDC25A can accumulate as a result of transcription activation of E2F-1
and c-myc and elevated levels of RNA and protein stimulate cells to enter the cell cycle.
Slingerland, "ER[alpha], SKP2 and E2F-1
form a feed forward loop driving late ER[alpha] targets and G1 cell cycle progression," Oncogene, vol.
Pena et al., "ATAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1
," Journal of Clinical Oncology, vol.
Alterations in histone modifications, decreased methylation of hTERT promoter, and increased binding of the hTERT repressor E2F-1
at the promoter were proposed as mediators of the observed bioactivity .
Selective inhibition of rRNA transcription downregulates E2F-1
: a new p53-independent mechanism linking cell growth to cell proliferation.
Fujimoto et al., "Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1
, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil," Oncology Reports, vol.
Arrest in the G0/G1 phase was associated with downregulation of the transcription factor E2F-1
and its target gene TS.
Constitutive expression of E2F-1
leads to p21-dependent cell cycle arrest in S phase of the cell cycle.
Treatment of VSMC with 4HNE or its glutathione conjugate (glutathionyl (GS-)HNE) or AR-catalyzed product of GS-HNE, GS-1,4-dihydroxynonane resulted in increased E2F-1
Regulation of FGF receptor-2 expression by transcription factor E2F-1
. Oncogene 22:5630-5635.