The technology is protected by a series of worldwide patents, including P-Esbp designed to target inflamed endothelial cells through recognition of E-selectin
for the inhibition of tumor growth and metastasis.
GlycoMimetics' wholly owned drug candidate, uproleselan, an E-selectin
antagonist, was evaluated in a Phase 1/2 clinical trial as a potential treatment for AML and is being evaluated across a range of patient populations including a company-sponsored Phase 3 trial in relapsed/refractory AML.
During the same period, we worked with clinical collaborators at Duke Cancer Institute to plan our next trial for GMI-1359, a dual antagonist of E-selectin
and CXCR-4, and defined individuals with breast cancer and bone metastases as our initial target study population," said CEO Rachel King.
Inhibition of E-selectin
expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis.
Findings from the Nurses' Health Study, published in the American Journal of Clinical Nutrition, found women who ate a westernized diet--high in red and processed meats, sweets, desserts, French fries, and refined grains--had higher rates of inflammation as noted by elevated levels of CRP, IL-6, E-selectin
, sVCAM-1, and sICAM-1, than those who consumed a diet rich in fruit, vegetables, legumes, fish, poultry, and whole grains.
Objective: To observe the changes and correlations of serum interleukins (ILs), adhesion molecules and soluble E-selectin
(sE-selectin) in children with allergic rhinitis, asthma and both diseases.
 reported that induction of mucosal tolerance to E-selectin
can prevent ischemic and hemorrhagic stroke in spontaneously hypertensive, genetically stroke-prone rats.
Soluble forms of these molecules such as E-selectin
(sE-selectin), intercellular adhesion molecule-1 (sICAM-1), and vascular cell adhesion molecule-1 (sVCAM-1) are released and may reflect overexpression of their respective membrane-bound forms .
Kobayashi et al., "Serum amyloid A promotes E-selectin
expression via toll-like receptor 2 in human aortic endothelial cells," Mediators of Inflammation, vol.
during inflammation plays an important part in recruiting leukocytes to the site of injury, and its potential role in the pathogenesis of PD was described .
Endothelial activation includes de novo gene expression, the synthesis of proinflammatory cytokines and adhesion molecules as well as increased expression of the adhesion molecules like E-selectin
, intracellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and increased permeability of the blood vessel.
When endothelial cells experience inflammation, they produce a molecule called "E-selectin
," which brings white blood cells (monocytes) to the area and causes plaque accumulation in the arteries.