E-selectin


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E-selectin

(ē-sē-lek'tin),
An adhesion molecule involved in leukocytotaxia, expressed on endothelial cells after stimulation by cytokines.
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The potential application of E-selectin in the clinic is based on the role that the compound plays in coordinating and responding to the immune system's activation and resulting response.
According to Paragon CEO Marco Chacon, PhD, "The Paragon team is happy to be a part of the process development and cGMP manufacturing of E-Selectin, a novel biologic of great clinical significance.
Results: The compounds and extract inhibited LPS- and TNF-[alpha]-induced upregulation of the proinflammatory molecules E-selectin and interleukin-8 in HUVECtert and THP-1 cells.
Circulating inflammatory biomarkers such as CRP, IL-6, TNF-[alpha], monocyte chemotactic protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), and E-selectin have been associated with a variety of metabolic disorders and associated outcomes (Goldberg 2009).
P- and E-selectin, which occur on inflamed endothelium, and their ligand, P-selectin glycoprotein ligand 1, are critical for the migration of Th1 cells to inflamed skin and peritoneum.
In fact, increased platelet activation (25) and elevated plasma markers such as endothelin-1 (17, 18, 26) and adhesion molecules ICAM-1, VCAM-1 and E-selectin (27) have been shown to be present in this context.
Plasma TNF-[alpha], soluble VCAM-1, and soluble E-selectin concentrations were measured with the Quantikine Human TNF-[alpha], Soluble VCAM-1, and sESelectin/CD62E kits from R&D Systems (R&D, USA).
The researchers whittled the field of potential biomarkers down to eight: prolactin, transthyretin, thrombospondin-1, E-selectin, C-C motif chemokine 5, macrophage migration inhibitory factor, plasminogen activator inhibitor 1, and receptor tyrosine-protein kinase erbB-2.
sICAM-1 concentrations significantly decreased after 6 hours of CW and CM interventions and E-selectin only decreased after CW intervention.
Amongst the serum analytes, levels of HDL, and NO were significantly low and that of, E-selectin and SVCAM1 were significantly higher in patients than the controls and hence an association of these parameters with the pathophysiology of CAD was envisaged.