E-cadherin

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u·vo·mo·ru·lin

(yū'vō-mō'rū-lin),

A transmembrane protein that links plasma membranes of adjacent cells together in a Ca²⁺-dependent manner; aids in maintaining the rigidity of the cell layer.

Synonym(s): E-cadherin

[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.

E-cadherin

(e?kad-her'in, -her')

A molecule that makes cells adhere (stick to) each other. Many malignant tumor cells stop producing normal amounts of E-cadherin, which seems to contribute to their ability to move away from the location where the primary tumor arises and invade other tissues. See: cadherin

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References in periodicals archive ?

Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer.

NDRG2 Regulates the Expression of Genes Involved in Epithelial Mesenchymal Transition of Prostate Cancer Cells

Antibodies specific to p-STAT3, STAT3, COX-2, MMP-2, MMP-9 were purchased from Cell Signaling Technology (Shanghai, China) while antibodies specific to E-cadherin, N-cadherin and Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were purchased from Proteintech (Wuhan, Hubei, China).

Baohuoside I Inhibits Benzo(a)Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT

The stainings of cyclins ([B.sub.1], [D.sub.1) and E-cadherin of MCF-7 control cells are shown in Figures 6a, b and c, respectively.

Multi-Mode Assessment Approach on Anti-Cancer Potency of Vanadium on Breast Cancer Cells

Adipose derived mesenchymal stem cells produce too much cytokines, bioactive matters, extracellular matrix proteins, as well as adhesion molecules (20).In a study, it has been shown that the co-culture with ADSCs increased both the N-cadherin and E-cadherin expression (27).

Evaluation of the effects of adipose-derived mesenchymal stem cells on intraperitoneal adhesions

Initially, the results of the RNA quantification assay and Western blot analysis [Figure 4]a and [Figure 4]b demonstrated that miR-340 mimics or anti-ROCK-1 siRNA could increase E-cadherin and decrease ROCK-1, N-cadherin, and vimentin.

MicroRNA-340 Inhibits Epithelial-Mesenchymal Transition by Impairing ROCK-1-Dependent Wnt/[beta]-Catenin Signaling Pathway in Epithelial Cells from Human Benign Prostatic Hyperplasia

The expression of E-cadherin in somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog response.

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly

In view of the important role of EMT in tumor metastasis during tumor progression [19, 20], we explored the effect of DAB2IP on EMT progress and revealed that DAB2IP can modulate the expression of EMT marker E-cadherin and vimentin in AGS and SGC7901 gastric cancer cells.

DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway

Snail and Slug/Snail2 are important EMT-inducing transcription factors, which could directly bond and inhibit E-cadherin transcription, which mediates drug resistance [64].

MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer

Level of E-cadherin expression in tumors of various grades was also taken into account.

HER2 Basolateral versus Circumferential IHC Expression Is Dependent on Polarity and Differentiation of Epithelial Cells in Gastric/GE Adenocarcinoma

However, it has been reported that diffuse GC as well as lobular breast carcinomas exhibited a reduced HER2 rate in comparison to frequent mutations of E-cadherin, with an inverse association [11, 22-24]; by contrast, in more than 50% of invasive cribriform breast carcinomas, a linear direct association between HER2 positivity and E-cadherin immunoreactivity has been already documented [25].

Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component

Pseudovillous trophoblastic proliferation present at the undersurface of the chorionic plate [(a) magnification x100, H&E], highlighted by double E-cadherin (brown)/CD34 (red) immunostain [(b) magnification x400].