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A transmembrane protein that links plasma membranes of adjacent cells together in a Ca2+-dependent manner; aids in maintaining the rigidity of the cell layer.
Synonym(s): E-cadherin
[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]


A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.


(e?kad-her'in, -her')
A molecule that makes cells adhere (stick to) each other. Many malignant tumor cells stop producing normal amounts of E-cadherin, which seems to contribute to their ability to move away from the location where the primary tumor arises and invade other tissues. See: cadherin
References in periodicals archive ?
Clinical and biological significance of e-cadherin protein expression, in invasive lobular carcinoma of the breast.
Ultrastrutural localization of E-cadherin cell adhesio molecule on the cytoplasmic membrane of keratinocytes in vivo and in vitro.
Increased internalization of p120-uncoupled E-cadherin and a requirement for a dileucine motif in the cytoplasmic domain for endocytosis of the protein.
AML shows promoter hypermethylation of p15 and E-cadherin genes (15,21).
The aim of the present study was to evaluate E-cadherin, Slug and NCAM expressions in GH-secreting pituitary adenomas and their relationship to the degree of tumor invasiveness.
Loss of membranous expression of E-cadherin is the defining immunohistochemical feature of lobular differentiation in breast carcinoma (Figure 5, A through C); consequently, E-cadherin is frequently employed by pathologists to make the distinction between LCIS and DCIS and between invasive lobular carcinoma and invasive ductal carcinoma.
Control group: Regular distribution of E-cadherin expression in the ganglionic layer, regular internal and external plexiform layers in cells in the inner and outer nuclear layers, E-cadherin immunohistochemical staining Bar 50 [micro]m.
La distribucion de la frecuencia de metilacion de cada GST en estudio, de los 30 pacientes, dio como resultado: 17 pacientes con metilacion para p15 (56,67%), 5 pacientes para E-cadherin (16,67%), 23 pacientes para p73 (76,67%) y 6 pacientes para RAR[beta]2 (20,0%).
The loss of E-cadherin expression has been noted in high-grade lesions of other cancers.
Objective: To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.