E-cadherin


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u·vo·mo·ru·lin

(yū'vō-mō'rū-lin),
A transmembrane protein that links plasma membranes of adjacent cells together in a Ca2+-dependent manner; aids in maintaining the rigidity of the cell layer.
Synonym(s): E-cadherin
[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.

E-cadherin

(e?kad-her'in, -her')
A molecule that makes cells adhere (stick to) each other. Many malignant tumor cells stop producing normal amounts of E-cadherin, which seems to contribute to their ability to move away from the location where the primary tumor arises and invade other tissues. See: cadherin
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References in periodicals archive ?
Clinical and biological significance of e-cadherin protein expression, in invasive lobular carcinoma of the breast.
Solving diagnostic dilemmas with Multiplex IHC: early changes and prognosis in breast cancer
Ultrastrutural localization of E-cadherin cell adhesio molecule on the cytoplasmic membrane of keratinocytes in vivo and in vitro.
E-cadherin expression in squamous cell carcinoma and basal cell tumors in dogs/Expressao da E-caderina em carcinoma de celulas escamosas e no tumor de celulas basais de caes
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Targeted suppression of Connexin 43 in ovine preimplantation embryos by RNA interference using long double-stranded RNA
co-expressed with E-cadherin throughout the entire nephron (Figures 3d-f and 4e-f).
Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae)/ Expressao das moleculas de adesao celular no desenvolvimento normal e com a inibicao do hormonio tireoidea do rim nas larvas do Bufo arenarum (Amphibia, Anura, Bufonidae)
Increased internalization of p120-uncoupled E-cadherin and a requirement for a dileucine motif in the cytoplasmic domain for endocytosis of the protein.
Cell-cell adhesion in the cnidaria: insights into the evolution of tissue morphogenesis
AML shows promoter hypermethylation of p15 and E-cadherin genes (15,21).
Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic & prognostic implication
The aim of the present study was to evaluate E-cadherin, Slug and NCAM expressions in GH-secreting pituitary adenomas and their relationship to the degree of tumor invasiveness.
Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly
Loss of membranous expression of E-cadherin is the defining immunohistochemical feature of lobular differentiation in breast carcinoma (Figure 5, A through C); consequently, E-cadherin is frequently employed by pathologists to make the distinction between LCIS and DCIS and between invasive lobular carcinoma and invasive ductal carcinoma.
Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants
Control group: Regular distribution of E-cadherin expression in the ganglionic layer, regular internal and external plexiform layers in cells in the inner and outer nuclear layers, E-cadherin immunohistochemical staining Bar 50 [micro]m.
Effects of Potentilla fulgens on the Changes Made in the Retinal Damage Induced by Traumatic Head Injury/ Efectos de Potentilla Fulgens en los Cambios Producidos Debido al dano Retinal Inducido por Lesion Traumatica en la Cabeza
La distribucion de la frecuencia de metilacion de cada GST en estudio, de los 30 pacientes, dio como resultado: 17 pacientes con metilacion para p15 (56,67%), 5 pacientes para E-cadherin (16,67%), 23 pacientes para p73 (76,67%) y 6 pacientes para RAR[beta]2 (20,0%).
Metilacion de genes supresores de tumores en pacientes venezolanos con leucemia linfoide aguda
The loss of E-cadherin expression has been noted in high-grade lesions of other cancers.
High-grade urothelial carcinoma of bladder transforming to micropapillary variant on follow-up
Objective: To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.
Expression of CD133, E-cadherin and WWOX in colorectal cancer and related analysis

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