E-cadherin


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u·vo·mo·ru·lin

(yū'vō-mō'rū-lin),
A transmembrane protein that links plasma membranes of adjacent cells together in a Ca2+-dependent manner; aids in maintaining the rigidity of the cell layer.
Synonym(s): E-cadherin
[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.

E-cadherin

(e?kad-her'in, -her')
A molecule that makes cells adhere (stick to) each other. Many malignant tumor cells stop producing normal amounts of E-cadherin, which seems to contribute to their ability to move away from the location where the primary tumor arises and invade other tissues. See: cadherin
References in periodicals archive ?
E-cadherin, which inhibits cancer cell migration and invasion, was reduced in B[a] P-treated groups relative to the control group, but expression of metastasis-promoting proteins, including N-cadherin, vimentin, snail, and slug, were induced after B[a]P exposure (Figure 2F).
Negative expression of the epithelial calcium-dependent adhesion molecule E-cadherin has been shown to be a sensitive and specific biomarker to confirm the invasive lobular carcinoma subtype among tumors with histologically equivocal features (18, 19).
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.
Immunohistochemical staining of oncocytoma areas (A) Positive E-cadherin expression (x400).
Aberrant expression of E-Cadherin in lobular carcinomas of the breast.
Immunohistochemical staining on FNA cell block preparations showed positive staining for E-Cadherin, CD10 (Figure 4), AMACR (Figure 5), and cytokeratin AE1/AE3.
4] Genes: E6, E6 transforming protein [human papillomavirus 18]; E2, E2 regulatory protein [human papillomavirus]; E7, E7 transforming protein [human papillomavirus]; TP53, tumor protein p53; IFNG, interferon, gamma; TMC6 (previously known as EVER1), transmembrane channel-like 6; TMC8 (previously known as EVER2), transmembrane channel-like 8; DAPK, death-associated protein kinase 1; CDH1, cadherin 1, type 1, E-cadherin (epithelial); RASSF1, Ras association (RalGDS/AF-6) domain family member 1; CDKN2A, cyclin-dependent kinase inhibitor 2A; FHIT, fragile histidine triad; MGMT, O-6-methylguanine-DNA methyltransferase; RARB, retinoic acid receptor, beta.
Absence of E-cadherin membranous staining is characteristic of lobular carcinomas, including PLC (Figure 2, D).
When E-Cadherin is lost, cells become 'rouge' - they can detach from their surrounding tissues, move effortlessly through the circulatory system, grow and attach at new sites," said Hari Koul, PhD, investigator at the CU Cancer Center and professor and director of Urology Research at the University of Colorado School of Medicine, the study's senior author.
Washington, April 3 ( ANI ): A University of Colorado Cancer Center study has described for the first time a switch that regulates the production of the protein E-Cadherin, the loss of which is a prerequisite for prostate cancer metastasis.
The switch from E-cadherin to N-cadherin is a well-known indicator of the epithelial-to-mesenchymal transition (EMT) occurring in bladder cancer.