eosinophilia-myalgia syndrome

(redirected from E-M syndrome)

eosinophilia-myalgia syndrome

 
a sometimes fatal syndrome of severe myalgia associated with marked peripheral eosinophilia, associated with the ingestion of oral preparations of l-tryptophan; long-term sequelae include scleroderma and progressive neuropathy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

e·o·sin·o·phil·i·a-·my·al·gi·a syn·drome (EMS),

a probable autoimmune disorder precipitated by contaminated l-tryptophan tablets; characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies, serum aldolase is increased, and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.
Synonym(s): E-M syndrome
Farlex Partner Medical Dictionary © Farlex 2012

e·o·sin·o·phil·i·a-my·al·gi·a syn·drome

(ē'ō-sin-ō-fil'ē-ă mī-al'jē-ă sin'drōm)
A probable autoimmune disorder precipitated by ingestion of contaminated l-tryptophan tablets, and characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies; serum aldolase is increased and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

eosinophilia-myalgia syndrome

A disorder featuring severe and persistent pain in the muscles, muscle weakness, loss of weight, fever, ‘pins and needles’ sensation (paraesthesia) and an exceptionally high level of EOSINOPHIL white cells in the blood. The cause is unknown but there is a strong association with ingestion of L-tryptophan.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005