dysplastic nevus

(redirected from Dysplastic Nevi)

dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dysplastic nevus

an acquired atypical nevus with an irregular border, indistinct margin, and mixed coloration, often occurring in large numbers and often a precursor of malignant melanoma.
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Dysplastic nevus

dysplastic nevus

Dermatology A premalignant skin lesion characterized by irregular, > 5 mm in diameter macules numbering from a few to hundreds with a central papule, variegated dark color and lenticular changes

dys·plas·tic ne·vus

(dis-plastik nēvŭs)
Skin malformation exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and colored tan-to-black and pink-to-red.
References in periodicals archive ?
There are two basic types of precancerous lesions associated with skin cancer: actinic keratoses and dysplastic nevi.
MYB1 loss appears particularly common in spitzoid neoplasms and is rare in dysplastic nevi, whereas the opposite seems to be true for RREB1.
Doctors believe that dysplastic nevi are more likely than ordinary moles to develop into a type of skin cancer called melanoma.
NRAS mutations have been documented in most congenital nevi but they are rarely seen in dysplastic nevi, (9) suggesting that congenital nevi and dysplastic nevi may arise through activation of different pathways in melanocytes.
Friedman uses several tools to examine suspicious pigmented lesions in patients who have lots of atypical moles or dysplastic nevi, or even a history of melanoma.
c-Kit expression decreases with melanoma progression: 55% of metastatic melanomas in Shen and colleagues' series (3) lacked expression of c-Kit versus 100% expression in dysplastic nevi and 96% in malignant melanomas.
It is best to eliminate doubt by completely excising dysplastic nevi slated for biopsy," Dr.
Histopathologic changes that mimicked partial regression occurred with increasing prevalence in 229 junctional dysplastic nevi according to the degree of cytologic atypia they exhibited: mild atypia (10%); moderate atypia (19%); and severe atypia (39%).
INK4a] a cyclin-dependent kinase inhibitor, is a relatively frequent genetic abnormality occurring in malignant melanomas and dysplastic nevi.
Sporadic dysplastic nevi show a high rate of loss of heterozygosity in chromosomes 1p and 9q (31); some variants show a predominant allelic deletion at chromosome 9p21 (p16 locus) that may be accompanied by deletion in 17p13 (p53 locus).
In one survey, 86% of dermatologists said they most often intend to remove dysplastic nevi completely, but only 67% said they would reexcise if the report indicated positive margins.
1,3) Atypical genital nevi are detected clinically during routine gynecologic examinations, as well as during pregnancy or during clinical surveillance because of a personal or family history of dysplastic nevi or melanoma.