dysplastic nevus

(redirected from Dysplastic Nevi)

dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dysplastic nevus

Dermatology A premalignant skin lesion characterized by irregular, > 5 mm in diameter macules numbering from a few to hundreds with a central papule, variegated dark color and lenticular changes

dys·plas·tic ne·vus

(dis-plastik nēvŭs)
Skin malformation exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and colored tan-to-black and pink-to-red.
References in periodicals archive ?
This can be difficult to distinguish from the bridging between adjacent rete ridges that is associated with dysplastic nevi, but the confluent growth of a melanoma often extends over the tops of the dermal papillae, rather than solely connecting the bases of adjacent rete ridges.
ORLANDO -- Re-excisions are not needed when clinically excised moderately dysplastic nevi have positive histologic margins, based on results of a retrospective study of 438 patients who were treat ed at nine academic medical centers in the United States.
[3, 4] Risk factors for malignant melanocytic lesions are both genetic and environmental, specially sunlight exposure in light coloured skin people, family history of melanomas, presence of multiple melanocytic nevi, xeroderma pigmentosum and dysplastic nevi. Early diagnosis helps in early treatment of the disease and decreased mortality rate.
The lesions were excised with a prediagnosis of dysplastic nevi. Histopathological examination revealed lentiginous hyperplasia, containing some small melanocytic nests at the dermoepidermal junction.
Common melanocytic lesions include lentigines, seborrheic keratosis, solar lentigo, freckles, blue nevi, melanocytic nevi, dysplastic nevi, pigmented squamous cell carcinoma, pigmented basal carcinoma etc.
A nevus is a mole, and abnormal moles are called dysplastic nevi. These can potentially develop into melanoma over time.
In dysplastic nevi and invasive melanoma cases positively stained cells were also counted in within and between nests of melanocytes (intratumoral location).
performed an immunohistochemical study, analyzing the expression of CEACAM1 in benign and malignant cutaneous tumors and in normal peritumoral skin: benign nevi (42 cases), dysplastic nevi (22 cases), thin superficial spreading melanomas (21 cases), and thick superficial spreading melanomas (21 cases).
Such nevi include dysplastic nevi (DN), congenital MN, and, to a lesser extent, acquired (common) MN (1).
Ackerman et al., "The histopathology of dysplastic nevi: continued controversy," American Journal of Dermatopathology, vol.
Malignant and potentially malignant diagnoses to consider include pigmented basal cell carcinoma, pigmented squamous cell carcinoma, carcinoma metastatic to the skin, and dysplastic nevi. (2,3)
(18.) Pellacani G, Farnetani E Gonzalez S, et al: In vivo confocal microscopy for detection and grading of dysplastic nevi: a pilot study.