hyaluronidase(redirected from Duran-Reynals spreading factor)
Also found in: Dictionary, Thesaurus, Encyclopedia.
1. an enzyme that catalyzes the hydrolysis of hyaluronic acid, the “cement material” of connective tissues; it is found in human testes, as well as in leeches, snake venom, and spider venom, and is produced by various pathogenic bacteria, enabling them to spread through tissue.
2. a preparation derived from the secretion of mammalian testes, used to promote absorption and diffusion of solutions injected subcutaneously. When it is mixed with fluids administered subcutaneously, absorption is more rapid and less uncomfortable. This is especially valuable when large amounts of fluid must be given by hypodermoclysis instead of intravenously. The hyaluronidase should be dissolved just before it is used and usually is injected with the first portion of the fluid to be given. Hyaluronidase should not be given in areas where there is infection. Since it hastens absorption, it must be given with caution when administered with toxic drugs, as a toxic reaction can occur rapidly.
1. Term applied loosely to hyaluronate lyase, hyaluronoglucosaminidase, and hyaluronoglucuronidase, one or more of which are present in sperm, the testes, and other organs, bee and snake venoms, type II pneumonococci, and certain hemolytic streptococci. Synonym(s): diffusing factor, Duran-Reynals permeability factor, Duran-Reynals spreading factor, invasin, spreading factor
2. A soluble enzyme product prepared from mammalian testes; it is used to increase the effect of local anesthetics and to permit wider infiltration of subcutaneously administered fluids, is suggested in the treatment of certain forms of arthritis to promote resolution of redundant tissue, is used to speed the resorption of traumatic or postoperative edema and hematoma, is used in combination with collagenase to dissociate organs, such as liver and heart, into viable cell suspensions, and in histochemistry is used on tissue secretions to verify the presence of hyaluronic acid or chondroitin sulfates.
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.
hyaluronidase(1) Hyaluronoglucosaminidase, EC 188.8.131.52.
(2) Hyaluronoglucuronidase, EC 184.108.40.206.
(3) Hyaluronate lyase, EC 220.127.116.11.
hyaluronidaseAn enzyme that breaks down proteins holding tissue planes together. Its use assists in the dispersal of tissue fluids or injected drugs. A brand name is Hyalase.
hyaluronidasean enzyme present in snake venom and bacteria that catalyses the hydrolysis of hyaluronic acid, thus making it ineffective in stopping the spread of invading microorganisms and other toxic substances.
Duran-Reynals,Francisco, U.S. bacteriologist, 1899-1958.
Duran-Reynals permeability factor - a soluble enzyme product prepared from mammalian testes. Synonym(s): hyaluronidase
Soluble enzyme product prepared from mammalian testes; used to increase the effect of local anesthetics and to permit wider infiltration of subcutaneously administered fluids, is suggested in the treatment of forms of arthritis to promote resolution of redundant tissue.