DurAct

bromfenac

An analgesic NSAID used for acute pain management, which was withdrawn from the market following multiple reports of liver failure.

DurAct®

Bromfenac Pain medicine A prescription NSAID-analgesic similar in efficacy to ibuprofen that was 'pulled' from the market by its producer, Wyeth-Ayerst, when it was linked to fulminant liver failure, death or need for liver transplantation
References in periodicals archive ?
71) Following reports of liver failure among long-term users of the drug, Wyeth voluntarily withdrew Duract from the market.
Against liability for private risk-exposure
And users of Rezulin, Baycol, Propulsid, Duract, and several drugs linked in hundreds of deaths before the drugs were "voluntarily" withdrawn by their manufacturers will likely encounter the same obstacle in states with shield laws.
Pillboxed in
The nonsteroidal inflammatory drug Duract, a Wyeth-Ayerst product, which was also known to cause liver damage, was approved although 19 similar drugs were already on the market.
Dangerous medicine: So what if the speedup at the FDA is putting poisons on pharmacy shelves? Congress doesn't want to know
For example, Duract, an effective short-term painkiller, proved dangerous when prescribed beyond 10 days, which doctors routinely did.
Manufacturers may promote off-label uses for drugs
Wolfe: Raw milk, aspirin and Reye's Syndrome, tampons and toxic shock, Phenformin and lactic acidosis, Posicor and Duract are all instances where there was clear, unequivocal data at the FDA showing harm, but where the FDA failed to either ban a product or require necessary labeling.
The Politics of Drug Safety
Drugs withdrawn between September 1997 and June of last year were Redux, Pondimin and Duract, all marketed by American Home Products Corp.
FDA Refines Approval Process
The withdrawals included the obesity drug Redux, the analgesic Duract, and the cardiac drug Posicor, which were withdrawn from the market for safety reasons within a year of approval.
THE FDA DEFENSE
Matrixx Initiatives' Duract cough suppressant tablets qualifies as a demand brand in the category, in part because it offers long-lasting relief and in part because of its unique form for a cough product.
Invest
The eight drugs lately withdrawn were GlaxoSmithKline's Lotronex, for irritable bowel syndrome; American Home Products' Redux, a diet aid; the Bayer Corporation's Raxar, an antibiotic; Pfizer's Trovan, also an antibiotic; Roche's Posicor, a blood-pressure medication; Wyeth-Ayerst's Duract, a painkiller; Warner-Lambert's Rezulin, a diabetes drug; and, this spring, Organon's Raplon, an anesthetic.
Undue Influence
s Seldane, an allergy medication that was recalled in February 1988 amidst reports of heart problems when used with other drugs; and Wyeth-Ayerst's Duract and Roche Laboratories Inc.
FDA Advisory Committee Reaffirms Safety of Rezulin
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