Dukes' classification

Dukes' classification

 [do̳ks]
a system of staging colorectal tumors based on evaluation of the depth of invasion of the carcinoma and the presence or absence of metastasis. The four stages are: A, confined to the mucosa and submucosa; B, invasion through the muscularis without lymph node involvement; C, invasion through the muscularis with regional node metastasis; and D, tumor metastasis to distant sites. See illustration.
 Modified Dukes' staging system for colorectal cancer. From Aspinall and Taylor-Robinson, 2001.

Dukes' classification

a staging system for colorectal tumors, from A to D, according to the degree of tissue invasion and metastasis. A Dukes' A tumor is one that is confined to the mucosa and submucosa. A B tumor is one that has invaded the musculature but has not involved the lymphatic system. C tumors have invaded the musculature with metastatic involvement of the regional lymph nodes. D tumors are those that have metastasized to distant organ tissues.
References in periodicals archive ?
On comparing the distribution of cases by Dukes' classification, they found a preponderance of Dukes' C tumors in patients undergoing APR and a relatively higher proportion of Dukes' A and B lesions in those undergoing AR.
Study design and validity Patients were stratified by site of cancer and Dukes' classification.
The type of follow-up was also not a predictor of survival in any subgroup analysis, as when controlling for adherence of tumor, Dukes' classification, or the tumor site (P = .