Dukes' classification

[do̳ks]

a system of staging colorectal tumors based on evaluation of the depth of invasion of the carcinoma and the presence or absence of metastasis. The four stages are: A, confined to the mucosa and submucosa; B, invasion through the muscularis without lymph node involvement; C, invasion through the muscularis with regional node metastasis; and D, tumor metastasis to distant sites. See illustration.

Modified Dukes' staging system for colorectal cancer. From Aspinall and Taylor-Robinson, 2001.

Dukes' classification

a staging system for colorectal tumors, from A to D, according to the degree of tissue invasion and metastasis. A Dukes' A tumor is one that is confined to the mucosa and submucosa. A B tumor is one that has invaded the musculature but has not involved the lymphatic system. C tumors have invaded the musculature with metastatic involvement of the regional lymph nodes. D tumors are those that have metastasized to distant organ tissues.

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References in periodicals archive ?

On comparing the distribution of cases by Dukes' classification, they found a preponderance of Dukes' C tumors in patients undergoing APR and a relatively higher proportion of Dukes' A and B lesions in those undergoing AR.

A study of the recurrence rates in patients with carcinoma anorectum undergoing abdominoperineal resection

Study design and validity Patients were stratified by site of cancer and Dukes' classification.

The type of follow-up was also not a predictor of survival in any subgroup analysis, as when controlling for adherence of tumor, Dukes' classification, or the tumor site (P = .