Duchenne muscular dystrophy(redirected from Duchenne type muscular dystrophy)
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Related to Duchenne type muscular dystrophy: Duchenne disease, pseudohypertrophic muscular dystrophy
the most common childhood muscular dystrophy, with onset usually before age 6 years. Characterized by symmetric weakness and wasting of first the pelvic and crural muscles and then the pectoral and proximal upper extremity muscles; pseudohypertrophy of some muscles, especially the calf; heart involvement; sometimes mild mental retardation; progressive course and early death, usually in adolescence. X-linked inheritance (affects males and transmitted by females).
Duchenne muscular dystrophy(do͞o-shĕn′)
A severe form of muscular dystrophy that begins in early childhood and almost exclusively affects males, characterized by progressive weakening of the muscles and usually leading to death from respiratory or cardiac failure. It is caused by lack of the protein dystrophin in muscle cells as a result of a recessive genetic mutation on the X chromosome.
Duchenne muscular dystrophyAn X-R disease caused by a deficiency of a muscle protein, dystrophin, which affects 1:3500 ♂, resulting in progressive muscular atrophy, wasting, and death by age 20, often related to respiratory–due to compromised diaphragm activity, or cardiac failure; calf and deltoid muscles display the typical finding of pseudohypertrophy. See Climbing up on oneself, Dystrophin, Pseudohypertrophy.
Duchenne muscular dystrophyA hereditary, X-linked RECESSIVE muscle disorder affecting males almost exclusively. It begins in the first three years of life and first affects the legs and buttocks. Usually, the muscles appear larger than normal (pseudo-hypertrophy) but are in fact very weak. The condition spreads to affect other muscles and death is usual between the age of 20 and 30. See also DYSTROPHIN. (Guillaume Benjamin Amand Duchenne, 1805–75, French neurologist).
Duchenne muscular dystrophy (DMD)
The most severe form of muscular dystrophy, DMD usually affects young boys and causes progressive muscle weakness, usually beginning in the legs.
Mentioned in: Muscular Dystrophy