Duchenne muscular dystrophy

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Related to Duchenne muscular dystrophy: Becker muscular dystrophy

Du·chenne dys·tro·phy

the most common childhood muscular dystrophy, with onset usually before age 6 years. Characterized by symmetric weakness and wasting of first the pelvic and crural muscles and then the pectoral and proximal upper extremity muscles; pseudohypertrophy of some muscles, especially the calf; heart involvement; sometimes mild mental retardation; progressive course and early death, usually in adolescence. X-linked inheritance (affects males and transmitted by females).

Duchenne muscular dystrophy

A severe form of muscular dystrophy that begins in early childhood and almost exclusively affects males, characterized by progressive weakening of the muscles and usually leading to death from respiratory or cardiac failure. It is caused by lack of the protein dystrophin in muscle cells as a result of a recessive genetic mutation on the X chromosome.

Duchenne muscular dystrophy

An X-R disease caused by a deficiency of a muscle protein, dystrophin, which affects 1:3500 ♂, resulting in progressive muscular atrophy, wasting, and death by age 20, often related to respiratory–due to compromised diaphragm activity, or cardiac failure; calf and deltoid muscles display the typical finding of pseudohypertrophy. See Climbing up on oneself, Dystrophin, Pseudohypertrophy.

Duchenne muscular dystrophy

A hereditary, X-linked RECESSIVE muscle disorder affecting males almost exclusively. It begins in the first three years of life and first affects the legs and buttocks. Usually, the muscles appear larger than normal (pseudo-hypertrophy) but are in fact very weak. The condition spreads to affect other muscles and death is usual between the age of 20 and 30. See also DYSTROPHIN. (Guillaume Benjamin Amand Duchenne, 1805–75, French neurologist).

Duchenne muscular dystrophy (DMD)

The most severe form of muscular dystrophy, DMD usually affects young boys and causes progressive muscle weakness, usually beginning in the legs.
Mentioned in: Muscular Dystrophy


1. pertaining to a muscle.
2. having well developed muscles.

muscular asymmetry
due usually to neuronal or disuse atrophy on one side of the body.
muscular atrophy
wasting away of muscle or a muscle because of reduction in cross sectional area of muscle fibers; may be due to disease of the muscle or its nerve supply, or to disuse or nutritional inadequacy. See also hereditary spinal muscular atrophy (below).
muscular degeneration
varies in severity from degeneration of only the myofibrils or degeneration of the myofibrils plus sarcoplasm, leaving satellite cells and myonuclei and sarcolemmal laminae unaffected, or further levels of increasing severity.
muscular denervation
destruction or congenital absence of the motor nerve supply to the muscle; manifested by paralysis and atrophy and absence of spinal reflexes.
muscular denervation atrophy
progressive shrinkage of muscle fibers when the nerve supply to the muscle is severed.
Duchenne muscular dystrophy
an X-linked inherited disease in humans, which is believed to be due to a deficiency of a membrane-associated protein, dystrophin. An analogous disease has been identified in Irish terriers, Golden retrievers and mice.
muscular dystrophy
any degenerative muscular disorder due to faulty nutrition of the muscles. Causes muscle weakness, liberation of myoglobin into the circulation from skeletal muscle and subsequent wasting and possible contracture. In humans there are a group of genetically determined, painless, degenerative myopathies that are progressively crippling because muscles are gradually weakened and eventually atrophy. In food animals the principal disease in this group is enzootic muscular dystrophy caused by a nutritional deficiency of selenium and/or vitamin E. Sporadic cases of muscular dystrophy of unknown etiology occur rarely in dogs.
muscular fascicle
muscular fasciculation
muscular fatigue
during brief, intense exercise probably due in large part to the accumulation of lactate.
hereditary spinal muscular atrophy
progressive degeneration of the motor cells of the spinal cord. It is an inherited, slowly progressive flaccid tetraparesis from an early age, with muscular atrophy. Occurs as an autosomal recessive trait in Swedish lapland dogs, a dominant trait in Brittany spaniels. Also reported in German shepherd dogs, English pointers and Rottweilers. See also hereditary neuronal abiotrophy of Swedish Lapland dogs. In cattle, inherited as an autosomal recessive trait and reported in Brown Swiss, Holstein-Friesian and Red Danish calves with an onset at 3 to 8 weeks of age. There is hind limb ataxia progressing to recumbancy. Associated with lesions in the lower motor neurons of the cervical and lumbar spinal cord.
muscular hernia
hernia through an enclosing muscle sheath.
muscular hyperplasia
an increase in the size of a muscle mass due to an increase in the number of muscle cells. See also myofiber hyperplasia, ileal muscular hypertrophy.
muscular hypertrophy
an increase in the size of a muscle mass due to an increase in the length and thickness of each muscle cell without any increase in the number of cells.
muscular ischemia
short duration or temporary or partial cessation of blood supply causes loss of muscle power and possibly some muscle fiber necrosis; long duration or severe or complete cessation cause ischemic muscle necrosis and atrophy. See also compartment syndrome, downer cow syndrome.
muscular ischemic necrosis
see ischemic myonecrosis.
muscular mineralization
ectopic deposition of minerals in muscle. See mineralization.
myelopathic muscular atrophy
muscular atrophy due to a lesion of the spinal cord, as in spinal muscular atrophy.
nutritional muscular dystrophy
see muscular dystrophy (above).
muscular parasitic diseases
includes cysticercosis, hepatozoonosis, Neosprum caninum myositis, sarcocystosis, toxoplasmosis, trichenellosis.
muscular receptors
muscle spindles which respond to stretch.
muscular steatosis
excess fat deposits in muscle; a problem only at meat hygiene inspection.
muscular vascular occlusive syndrome
see ischemic myonecrosis.
muscular weakness
X-linked muscular dystrophy
see Duchenne muscular dystrophy (above).
References in periodicals archive ?
The company's lead candidate, CAP-1002, is an "off-the-shelf" cardiac cell therapy that is currently in clinical development for the treatment of Duchenne muscular dystrophy.
Dental characteristics of patients with Duchenne muscular dystrophy.
Most research into treatments for Duchenne muscular dystrophy patients has focused on the skeletal muscle aspects of the disease, but more often than not, the cause of death has been the heart failure that affects Duchenne patients," said Eduardo Marb[sz]n, MD, PhD, director of the Cedars-Sinai Heart Institute and study leader.
The first scientific evidence on the beneficial effect of steroids in Duchenne muscular dystrophy was documented over 40 years ago by Drachman et al.
A snapshot of the global therapeutic scenario for Duchenne Muscular Dystrophy.
In this study we show the same types of improvement in a mouse model of Duchenne muscular dystrophy.
With today s office opening, the new company can now begin to fully undertake development of a treatment for Duchenne muscular dystrophy.
But mum Joanne is determined to fight the condition and has thrown her weight behind the Muscular Dystrophy Campaign's Duchenne Research Breakthrough Fund, set up to accelerate the pace of promising research which scientists say could offer f the first treatment for Duchenne muscular dystrophy.
Kate Willoughby, who is swimming to raise cash for the fatal childrens' disease Duchenne Muscular Dystrophy, which her six-year-old nephew Harrison has, will set off from Baja California Island at dawn on November 21.
Thirteen patients (aged 5-10 years) with Duchenne muscular dystrophy who were on stable prednisone therapy for more than 6 months were treated with coenzyme Q10 (CoQ10).
NEWBORN baby boys will no longer be tested for the incurable condition Duchenne muscular dystrophy in Wales.