Improved assay to detect neutralizing antibody following vaccination with diluted or undiluted vaccinia (Dryvax
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000 compared with Dryvax
. Hum Vaccin Immunother 2013;9:1489-96.
In June 2015, ACIP, having reviewed recent clinical data, reaffirmed the CDC's standing recommendations that the live vaccinia virus smallpox vaccine ACAM2000 (which replaced Dryvax
in 2008) be administered routinely to those with occupational exposure to orthopox viruses (eg, laboratory personnel who work with monkeypox, variola, or smallpox viruses).
Since then, the immunosignature evoked by three different vaccines (Acam2000, Dryvax
, and MVA) in the mouse, rabbit, macaque, prairie dog, and humans have been defined [47-50].
Improved assay to detect neutralizing-antibody following vaccination with diluted or undiluted vaccinia (Dryvax
, the only other smallpox vaccine that is licensed by the FDA, was approved in 1931 and is now in limited supply because it is no longer manufactured.
Acambis is investigating the side-effects, also seen in patients on rival drug Dryvax
There will be no study to test the Dryvax
smallpox vaccine in children as preparation for a bioterrorism attack, the Office of Human Research Protection of the U.S.
In primary vaccinees, the Dryvax
package instructions are to give two or three insertions with the bifurcated needle.
The FDA relicensed Dryvax
vaccine produced by Wyeth Lederle, with the production of a new vaccine-Acam--expected to be completed in May 2003, and licensure in early 2004.
15.4 million doses of the smallpox (Dryvax
) vaccine available.
Since 2001, when the previous ACIP recommendations were developed, ACAM2000 has replaced Dryvax
as the only smallpox vaccine licensed by the U.S.