keratoconjunctivitis sicca

(redirected from Dry eye disease)

keratoconjunctivitis

 [ker″ah-to-kon-junk″tĭ-vi´tis]
inflammation of the cornea and conjunctiva.
epidemic keratoconjunctivitis a highly infectious form, commonly with regional lymph node involvement, occurring in epidemics; an adenovirus has been repeatedly isolated from affected patients.
phlyctenular keratoconjunctivitis a form marked by formation of a phlyctenule (small lesion) at the corneal limbus.
keratoconjunctivitis sic´ca a condition marked by hyperemia of the conjunctiva, thickening and drying of the corneal epithelium, and itching and burning of the eye. Called also dry eye.

ker·a·to·con·junc·ti·vi·tis sic·ca

keratoconjunctivitis associated with decreased tears.
See also: Sjögren syndrome.

keratoconjunctivitis sicca

dryness of the cornea caused by a deficiency of tear secretion in which the corneal surface appears dull and rough and the eye feels gritty and irritated. The condition may be associated with erythema multiforme, Sjögren's syndrome, trachoma, and vitamin A deficiency. Methylcellulose artificial tears may give some relief, as can insertion of plugs into the punctae and use of cyclosporine drops.
Dryness of eyes, often due to decreased tear secretion, which occurs in Sjögren syndrome, autoimmune disorders—systemic lupus, rheumatoid arthritis, scleroderma, sarcoidosis—amyloidosis, hypothyroidism, vitamin A deficiency, and in periorbital lymphoproliferative disorders

ker·a·to·con·junc·ti·vi·tis sic·ca

(ker'ă-tō-kŏn-jŭngk'ti-vī'tis sik'ă)
A chronic mucopurulent conjunctivitis, sometimes leading to corneal ulceration and scarring, due to deficit of the aqueous component of tears.
Synonym(s): dry eye syndrome.

keratoconjunctivitis sicca

Dry eye. A state of inadequate wetting and lubrication of the cornea as a result of defective tear production. This results from damage to the tear glands by the same AUTOIMMUNE DISEASE process that causes RHEUMATOID ARTHRITIS, SJOGREN'S SYNDROME, systemic lupus erythematosus and other related conditions. Dry eye is common in all these disorders. There is constant discomfort, foreign-body sensation and sometimes pain and the condition may progress to infection and ulceration of the cornea. Treatment is by the regular use of artificial tears.

ker·a·to·con·junc·ti·vi·tis sic·ca

(ker'ă-tō-kŏn-jŭngk'ti-vī'tis sik'ă)
A chronic mucopurulent conjunctivitis, sometimes leading to corneal ulceration and scarring.
Synonym(s): dry eye syndrome.

keratoconjunctivitis sicca (ker´ə-tōkənjungk´tivī´tis sik´ə),

keratoconjunctivitis

inflammation of the cornea and conjunctiva.

chronic immune-mediated keratoconjunctivitis syndrome
see chronic superficial keratitis.
infectious keratoconjunctivitis
see also infectious bovine kerato conjunctivitis. Caused by Moraxella bovis, Histoplasma capsulatum, Chlamydiae, Mycoplasma spp.
proliferative keratoconjunctivitis
see nodular fasciitis.
keratoconjunctivitis sicca
a condition marked by hyperemia of the conjunctiva, thickening and drying of the corneal epithelium, secondary to quantitative and qualitative deficiencies in the tear film. Deep keratitis and corneal ulceration may occur. Often a tenacious, stringy mucoid discharge accumulates in the conjunctival sac. Called also dry eye.
References in periodicals archive ?
is rolling out Restasis, approved late last year by the Food and Drug Administration as the first therapeutic treatment for increasing tear production in patients with chronic dry eye disease (CDED) due to ocular inflammation.
LipiView([R])provides detailed digital images of a dry eye patient's tear film for the physician to assess the lipid layer while the LipiFlow([R]) treats a root cause of evaporative dry eye disease by unblocking obstructed Meibomian glands located in the eyelids during an in-office procedure.
The markets for Surface's drug candidates include dry eye disease and blepharitis, both of which exceed USD 1bn in annual US pharmaceutical sales.
According to the company, it is targeting Dry Eye Disease (DED) with Lamelleye, Radiotherapy-Induced Xerostomia (RIX) with Visco-ease as well as Cystic Fibrosis (CF) with Muco-ease.
Another study showed that patients with evaporative dry eye disease, as well as those with acqueous-deficient dry eye disease, improved when treated with Optive Fusion for 90 days.
The R&D Leadership Team will highlight a number of programs in Shire s research portfolio, as well as provide updates on several clinical programs in development, including SHP606 (lifitegrast) in Dry Eye Disease, SHP625 (LUM001) in Cholestatic Liver Disease, SHP626 (LUM002) for adults with Nonalcoholic Steatohepatitis (NASH), and SHP607 for the prevention of Retinopathy of Prematurity (ROP).
Despite the gain in knowledge of pathogenic factors of dry eye disease acquired in the past 30 years, there has been a lack of consensus on the aim of specific diagnostic tests, the role of subjective symptoms, and the interpretation of results.
In a clinical study of canine dry eye disease, an aqueous solution of SCY-641 was well tolerated and significantly improved tear production.
Advanced Dry Eye Disease may damage the front surface of the eye and ultimately impair vision.
The company will lead development of P-321, an investigational epithelial sodium channel inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund.
The eyelid heat mask for the relief of various eye conditions, including blepharitis and dry eye disease, won the Queen's Award for Enterprise in the innovation category.
DISCUSSION: Rosenberg and Asbell[17] recently performed an analysis of all currently published literature on omega-3 fatty acids and dry eye disease and found that although correlation exists between essential fatty acids supplementation and dry eye disease, strong conclusions still cannot be made because of limitations in research reported.