drusen


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drusen

 [droo´sen]
1. abnormal growths of hyaline in Bruch's membrane, the inner layer of the choroid of the eye, usually due to aging.
2. rosettes of granules occurring in the lesions of actinomycosis.

dru·sen

(drū'sen),
Small bright structures seen in the retina and in the optic disk.
[Ger. pl. of Druse, stony nodule, geode]

drusen

Ophthalmology Acellular and amorphous, yellow-white, occasionally confluent nodules composed of aggregated abnormal glycoproteins and glycolipids produced by, and adjacent to, the basal cells of the retinal pigment epithelium

dru·sen

(drū'sĕn)
Small, bright structures seen in the retina and in the optic disc.
[Ger. pl. of Druse, stony nodule, geode]

Drusen

Tiny yellow dots on the retina that can be soft or hard and that usually do not interfere with vision.
Mentioned in: Macular Degeneration

drusen

Small, circular, yellow or white dots located throughout the fundus but more so in the macular region, around the optic disc or the periphery. They consist of deposits of abnormal extracellular material (amyloid P, complement proteins (C3, C5, C5b-9 complex), factors C, apolipoproteins B and E, lipids, vitronectin, etc.) derived mainly from the retinal pigment epithelium (RPE) and neural retina and they are located between the basement membrane of the RPE and Bruch's membrane. Drusen interfere with the blood supply to the photoreceptors. Although they may be found in young people, they almost universally occur with ageing but also with retinal and choroidal degeneration (e.g. age-related maculopathy, retinitis pigmentosa, angioid streaks) and primary dystrophy (e.g. fundus flavimaculatus). There are several main types of drusen: (1) Hard (or nodular) drusen are small, round and discrete. They are deposits of granular material as well as of abnormal collagen. They are the most common type and are usually innocuous. (2) Soft (or diffuse or granular) drusen are often large with indistinct edges and with time they may enlarge, coalesce and increase in number. They are due to either a focal thickening of the inner layer of Bruch's membrane or to amorphous material located between that thickened, detached part and the rest of Bruch's membrane. They represent an early feature of age-related macular degeneration. (3) Cuticular (or basal laminar) drusen are small subretinal nodular thickening of the basement membrane of the pigment epithelium. They occur in younger patients more often than hard or soft drusen. (4) With time, the above drusen may calcify (calcific drusen) and take on a glistening appearance. Drusen rarely produce any symptoms and if there is a visual loss it is usually due to an accompanying macular haemorrhage, but if the drusen are very large thus widening the separation between the RPE and Bruch's membrane there may be a degeneration of the overlying RPE and photoreceptors (Fig. D11). Syn. colloid bodies; hyaline bodies. See age-related macular degeneration; choroidal naevus.
familial dominant drusen An autosomal dominant hereditary degeneration of the choroid characterized by light-coloured patches of colloid material in the area around the macula and often the optic disc. The majority of cases are caused by mutations in the EFEMP1 gene (egf-containing fibulin-like extracellular matrix protein 1). There is no loss of vision unless it is followed by macular degeneration. Syn. Doyne's honeycomb choroiditis; Doyne's honeycombed degeneration; Tay's choroiditis (used more commonly for the elderly).
optic disc drusen Whitish-yellow spherical excrescences that lie on, or within, or occasionally around the optic nerve head. They are composed of calcified hyaline-like material possibly resulting from deposition of mucoprotein and calcium that have extruded from degenerating axons. In childhood they are usually buried within the disc substance and thus not visible on clinical examination but cause elevation of the disc surface resembling papilloedema. With age they become progressively more superficial. Field defects are common (e.g. generalized constriction, blind spot enlargement) but visual acuity is normal, unless there is some vascular complication. They usually appear bilaterally and affect males and females equally. They are easily diagnosed with fluorescein angiography because exposed drusen are autofluorescent.
Fig. D11 Calcified drusenenlarge picture
Fig. D11 Calcified drusen
References in periodicals archive ?
Autofluorescence distribution associated with drusen in age-related macular degeneration.
Using MAC immunofluorescence, they found that in eyes with early AMD, small hard drusen were almost invariably labeled with anti-MAC antibody.
The role of tau in AMD is debated and likely underestimated, as tau has not been found in drusen, but has been reported in OPL, INL, IPL, and NFL of patients with AD.
These surrogate endpoints include slowing or eliminating the progression of dry AMD to wet AMD, reducing the treatment interval and burden for patients with wet AMD undergoing anti-VEGF therapy, eliminating or reducing the drusen burden in the macula, and slowing the enlargement rate of GA.
Similar were the observations in a study on French AMD patients.21 Lipoproteins that pass through and accumulate in RPE and Bruch's membrane provide substrate for initial changes of AMD-like drusen formation.
In summary, with aging and chronic oxidative stress due to UV light or cigarette smoke and impaired antioxidant enzyme function, photoreceptor damage and death accelerate, drusen deposits form, and inflammation increases [54].
According to their results, it was determined that fundus photography best specifies the drusen and RPE variations in case of ARMD.
Drusen in the macula are a common early sign of AMD that can be defined as hard and soft.
Key words: Macular degeneration, aged; Retinal drusen; Retina; Sex; Male; Female
The drusen themselves don't seem to cause blindness, but as they increase, your risk of developing advanced dry macular degeneration or the more serious, wet form of the disease increases.
Some 4203 individuals (mean age, 73 years) participating in the Age-Related Eye Disease Study 2 (AREDS2), who were at risk of progression to advanced age-related macular degeneration (because of the presence of bilateral large drusen or large drusen in 1 eye and advanced macular degeneration in the other eye), were randomly assigned to receive, in double-blind fashion, daily supplementation with lutein (10 mg) plus zeaxanthin (2 mg), omega-3 fatty acids (650 mg of EPA and 350 mg of DHA), both treatments, or placebo.
I diagnosed drusen which can be a precursor to age-related macular degeneration.