drug tolerance


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Related to drug tolerance: drug withdrawal

tolerance

 [tol´er-ans]
1. the ability to bear something potentially difficult.
2. the ability to endure unusually large doses of a poison or toxin.
3. drug tolerance. adj., adj tol´erant.
acquired drug tolerance drug tolerance.
ambiguity tolerance the ability to withstand conflicting or complex situations without undue psychological stress.
drug tolerance a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. See also drug dependence and habituation.
immunologic tolerance specific nonreactivity of lymphoid tissues to a particular antigen capable under other conditions of inducing immunity.
standing tolerance the amount of time an individual is capable of maintaining an erect, upright position.
tolerance test
1. an exercise test to determine the efficiency of the circulation.
2. a test to determine the body's ability to metabolize a substance or to endure administration of a drug.

drug tolerance

a condition of cellular adaptation to a pharmacologically active substance so that increasingly larger doses are required to produce the same physiological or psychological effect obtained earlier with smaller doses. Also called metabolic tolerance. See also tachyphylaxis.

drug tolerance

Psychiatry Repeated use of some substance or drug, often narcotics, so that ever larger doses are required to produce the same physiologic and/or psychologic effect obtained previously by a smaller dose.

drug tolerance

A progressive reduction in the effect of a drug, following repeated exposure to it, so that it no longer has the desired effect in the original dose.

tolerance

the ability to endure without effect or injury.

drug tolerance
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
high-dose tolerance
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
immunological tolerance
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
tolerance level
the concentration of a drug or chemical permitted by law to be present in human food.
tolerance limits
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
low-dose tolerance
that induced by repeated administration of low doses of the antigen.
oral tolerance
that induced by oral administration of the antigen.
self-tolerance
the non-reactivity of the immune system to self-antigens.
tolerance test
see tolerance test.
zero tolerance
when no detectable amount of a chemical substance is permitted in human food.
References in periodicals archive ?
Several recent reports have begun to extend the Pavlovian conditioning model of drug tolerance to other forms of homeostatic challenges or stressors (Kissinger & Riccio, 1995; Poulos & Cappell, 1991; Riccio, MacArdy, & Kissinger, 1991), and one such challenge involves the thermoregulatory system.
If resistance to hypothermia and drug tolerance are analogous phenomena, tolerance to hypothermia should be disrupted by this manipulation.
These data indicate that, as expected, the animals allowed to rest on Days 6-10 did not demonstrate a loss of tolerance; consistent with the literature on drug tolerance, adaptation was well retained over a several day interval (e.
Although there is no way to equate extinction "trials" in cold tolerance with "placebo" exposures in drug tolerance, the results of the present experiment may parallel other experiments (Siegel et al.
Greenberg's team reports encouraging efficacy and drug tolerance results in a Phase II trial with patients who had all failed the standard hypomethylating agent treatments (Abstract #4010).
Confirmation that genotyping of patients prior to treatment allows for optimized personalized dosing and improved drug tolerance.
A personAaAeAe drug tolerance can diminish during their time in jail, so the risk of overdose is higher.
The study seeks to show that ACCLAIM, by combining L-arginine with a long acting nitrate, can eliminate drug tolerance and provide patients with an improved cardiovascular health benefit compared to standard nitrate products.
A personEs drug tolerance can diminish during their time in jail, so the risk of overdose is higher.
She also worked jointly with the National Institute of Justice and the Federal Bureau of Prisons on the successful "Zero Drug Tolerance Program," which used trace detectors to halt the influx of drugs into prisons.
Greater drug tolerance was observed with CPI-0004 which permitted 3 to 16 fold higher doses of doxorubicin.