APO-Flutamide (CA), Drogenil (UK), Euflex (CA), Novo-Flutamide (CA), PMS-Flutamide (CA)

Pharmacologic class: Antiandrogen

Therapeutic class: Antineoplastic

Pregnancy risk category D


Exerts potent antiandrogenic activity at cellular level by inhibiting androgen uptake or nuclear binding of androgen


Capsules: 125 mg

Indications and dosages

Metastatic prostate cancer

Adults: 250 mg P.O. t.i.d. q 8 hours, given with luteinizing hormone-releasing hormone (LHRH) analog. Total daily dosage is 750 mg.

Off-label uses

• Benign prostatic hypertrophy


• Hypersensitivity to drug
• Severe hepatic impairment
• Sleep apnea
• Women




• Be aware that leuprolide acetate is the most common LHRH analog given with flutamide.

Adverse reactions

CNS: drowsiness, confusion, depression, anxiety, nervousness, paresthesia

CV: peripheral edema, hypertension

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, anorexia, dry mouth

GU: erectile dysfunction, loss of libido, gynecomastia, hot flashes

Hematologic: anemia, leukopenia, thrombocytopenia

Hepatic: hepatitis

Skin: rash, photosensitivity


Drug-drug.Warfarin: increased prothrombin time

Drug-diagnostic tests.Alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatine kinase: increased levels

Hemoglobin, platelets, white blood cells: decreased levels

Drug-herbs.Chaparral, comfrey, eucalyptus, germander, pennyroyal, skullcap, valerian: increased risk of hepatotoxicity

Drug-behaviors.Sun exposure: increased risk of photosensitivity

Patient monitoring

• Monitor CBC and liver function tests.

Watch for bleeding tendency and signs and symptoms of hepatic damage (jaundice, vomiting, dark yellow or brown urine).
• Monitor blood pressure.

Patient teaching

Instruct patient to immediately report unusual bleeding or bruising.
• Tell patient to avoid activities that can cause injury. Advise him to use soft toothbrush and electric razor to avoid gum and skin injury.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Instruct patient to minimize GI upset by eating frequent, small servings of healthy food.
• Tell patient he'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


A brand name for FLUTAMIDE.
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Avodart, Zoladex, Proscar, Casodex, Taxotere, Satraplatin, Plenaxis, EULEXIN, Trelstar Depot, Trelstar LA, Viadur, Gleevec, Avastin, Herceptin, Atrasentan, Acapodene, Actimid, OSI-461, Revimid, Eladem, GTI-2501, ILX-651, calcitrol, Genasense, Provenge , GVAX, SGN-15, Thalomid, Velcade, Lupron Depot, Histrelin, Eligard, ILX651, Vitaxin, J591, CG7870, BBR-3576, PCK3145, Leuvectin, Leuprolide, ProMaxx-100, Osaterone, Prinomastat, BLP25, Metaret, Chimax, Drogenil, Flutamide, EULEXIN, Onconase, IM862, MDX-010, Erbitux, Eladem, GTI-2040, Apomine, Eflornithine, Doxil, GTI-2501, Thalidomide, TG4010, KRX-0401, Yondelis, TRICOM Vaccine, Zarnestra