BACE2

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BACE2

A gene on chromosome 21q22.3 that encodes beta secretase 2, a transmembrane enzyme responsible for the proteolysis of the amyloid precursor protein, leading to the generation and extracellular release of beta-cleaved soluble AP. It is expressed at low levels in most peripheral tissues and at higher levels in the colon, kidney, pancreas, placenta, prostate (in benign and malignant ducts), stomach and trachea.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
A statement issued by the Ministry of National Health Services said that Drap has taken concrete steps to strengthen its systems to ensure public access to safe and quality medicines.
In order to eradicate menace of spurious, smuggled and unregistered medicine from market and protect public, DRAP has created 25 posts for federal inspectors of drugs to be posted throughout the country.
DRAP had been advised to monitor MRPs in the market to ensure that the same were not higher than the notified prices, he added.
DRAP has involved 10 pharmaceutical manufacturers in testing phase for smooth running for the online system.
The DRAP official was of the view that the Federal Minister and Secretary National Health Services, Regulations and Coordination had already directed DRAP to take strict action against pharmaceutical companies selling medicines on exorbitant prices.
'With the approval of the federal government and cabinet decision dated 20.12.2018, Dr Sheikh Akhter Hussain, is appointed as Chief Executive Officer (CEO) Drug Regulatory Authority of Pakistan under Ministry of NHS, R and C, on contract basis for a period of three years, in terms of Section 5 of the DRAP Act, 2012, with immediate effect and until further orders,' the notification issued by the Ministry of National Health Services read.
He said that with the support of provincial governments, DRAP is determined to grab the culprits with iron hands and in this regard various activities have been done by DRAP with provincial governments.
Chairman DRAP welcomed the proposal and also said that operations and regulations of DRAP are being restructured and transformed on modern scientific basis.
The three-member bench was informed that NAB had withdrawn the notice against DRAP and the proceedings against the accused had been closed.
The Official describing the function of the system also said that medical facility carrying the responsibility of treatment will also provide the record of patient and the stent to DRAP.
In this regards, DRAP has implemented Integrated Regulatory Information Management System (IRIMS) for online submission of fee, registration application, renewal of registration for drugs and post registration variations.