Dramamine


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Dramamine

 [dram´ah-mēn]
trademark for preparations of dimenhydrinate or meclizine hydrochloride, antihistamines effective against nausea and vomiting, especially in motion sickness, and vertigo.

dimenhydrinate

Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B

Action

Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain

Availability

Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)

Contraindications

• Hypersensitivity to drug or tartrazine

• Alcohol intolerance

Precautions

Use cautiously in:

• angle-closure glaucoma, seizure disorders, prostatic hypertrophy

• children younger than age 2.

Administration

• For I.V. use, dilute with dextrose 5% in water or normal saline solution.

• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site

Interactions

Drug-drug. Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.

• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol and sedative-hypnotics during therapy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Dramamine

(drăm′ə-mēn′)
A trademark for the drug dimenhydrinate.
References in periodicals archive ?
The authors found that in laboratory animals (mice and rats), and in cell culture models, meclizine (one of two drugs marketed as Dramamine) helped to protect hearts from injury due to decreased blood flow.
In addition to doxylamine and diphenhydramine, we can consider using dimen-hydrinate (Dramamine), meclizine (An-tivert), hydroxyzine (Vistaril, Atarax), and cetirizine (Zyrtec).
Fortified with Dramamine, I steadied my position and focused on the outline of the nearby Atlantis resort as the waves seemed to pitch the property up and down on the horizon.
Over-the-counter antihistamines, such as meclizine (Antivert, Bonine), dimenhydrinate (Dramamine), and diphenhydramine (Benadryl) are commonly used for prevention.
He's got a laptop, a theory about how the atmosphere swirls around Greenland's icy bulk, and enough Dramamine to last for 17 turbulent flights over the raging northern oceans.
"I tried taking Dramamine, but that made me sleepy," said McWilliams, who's taking pre-calculus, literature, economics, Spanish literature and Spanish history this term.
Existen medicamentos obtenibles sin receta, tales como la mezclicina o el dimenhidrinato (Dramamine), que previenen el mareo por movimiento.
Besides over-the-counter medication, such as Dramamine, some cruise passengers have obtained relief from the spice
As I watch Martin Lawrence, through my Dramamine haze, running along the beach in a fat suit, braids, and bathing suit, I wonder, Why couldn't he make this funny?
Thanks to drugs (Dramamine) and smart eating strategies, most off us can be spared this gut wrenching experience.
When exactly do I get those "sea legs?" Time to pop the Dramamine.