Dramamine


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Dramamine

 [dram´ah-mēn]
trademark for preparations of dimenhydrinate or meclizine hydrochloride, antihistamines effective against nausea and vomiting, especially in motion sickness, and vertigo.

dimenhydrinate

Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B

Action

Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain

Availability

Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)

Contraindications

• Hypersensitivity to drug or tartrazine
• Alcohol intolerance

Precautions

Use cautiously in:
• angle-closure glaucoma, seizure disorders, prostatic hypertrophy
• children younger than age 2.

Administration

• For I.V. use, dilute with dextrose 5% in water or normal saline solution.
• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site

Interactions

Drug-drug.Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests.Allergy skin tests: false-negative results

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.
• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.
• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Caution patient to avoid alcohol and sedative-hypnotics during therapy.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Dramamine

(drăm′ə-mēn′)
A trademark for the drug dimenhydrinate.

Dramamine

a trademark now used for two different antiemetics, dimenhyDRINATE, and more recently meclizine (causes less sedation).
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Either the Dramamine was hitting her fast or it was just the contact high.
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Pop some Dramamine for the 33-mile Million Dollar Highway segment linking Ouray and Silverton, where S-curves and drop-offs make the 25-mph speed limit seem reckless.
I had a book group do that last week and I was in serious need of Dramamine by the time we were finished.
0 it bought the motion sickness medicine Dramamine from Johnson & Johnson.
El juego contra Forlan y los suyos equivalia a tres posibles victorias, dosis desmesurada en un pais que no encuentra el Dramamine emocional para el mareo de "dar el salto".
Fearing a mutiny, Jet Ski made a quick trip to the pharmacy for special seasick bracelets and Dramamine pills, the former of which worked well enough to get everyone shred-ready.
Smouha, "Acute labyrinthitis may be treated with meclizine or Dramamine to improve motion sickness, and usually improves over a few days to a couple of weeks.
but remembered - landlubber that I am - a full supply of Dramamine, two doses of which I ingested about an hour prior to our journey.