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A test to determine the degree to which a substance such as a cosmetic or pharmaceutical irritates human tissues, in which a small amount of the substance is applied directly in the eye of a rabbit, and the rabbit is then monitored.
a controversial method of testing the toxicity of pharmaceutic and other products to be used by humans by placing a small amount of the substance in the eyes of rabbits. The eye-irritancy potential of a substance is considered a measure of the possible effect of the product on similar human tissues. The Draize in vivo test is recognized by the U.S. Food and Drug Administration as a reliable method of predicting the risk of new products to human eyesight, although alternative testing methods are being sought.