In Figure 3, red indicates the upregulated and green the downregulated
mRNAs between the two lines.
Eight of the miRNAs were downregulated
in BC cases--by 3.
In order to examine the significance of downregulated
Interestingly, we found that survivin is transcriptionally downregulated
and proteasome-degraded by TIIA in an array of TRAIL-resistant ovarian cancer cell lines.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated
genes in the H group), systemic lupus erythematosus (14/16 downregulated
genes in the H group) and ECM -receptor interactions (7 downregulated
genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.
GRHL2 overexpression was detected in several cancers; however, in certain subclasses of breast cancer, GRHL2 was downregulated
The first question was whether RbAp48 is downregulated
in aged mice, and indeed, that turned out to be the case-there was a reduction of RbAp48 protein in the DG, lead author Elias Pavlopoulos, PhD, associate research scientist in neuroscience at CUMC said.
Betulinic acid (BA) and curcumin inhibited bladder cancer cell growth and downregulated
specificity protein (Sp) transcription factors, and this was accompanied by decreased expression of EGFR mRNA and protein levels.
In contrast, the 5-HT protein transporter was downregulated
in females (Aldridge et al.
100 genes were identified as being either up- or downregulated
in node-negative breast cancer.
Philip Gold, chief of the clinical neuroendocrinology branch at the National Institute of Mental Health, re viewed research showing that the hypo thalamic pituitary axis is downregulated
in chronic fatigue syndrome.
We found that key myeloid genes were upregulated in the cells, and that lymphoid-associated genes were downregulated
," said Viatour.