Meanwhile, 170 genes deregulated by ESE, and 55 genes deregulated by APE when tested alone, were not up- or downregulated
2, the following GO annotations were revealed: 76 GO molecular functions were annotated with 239 genes, of which 149 were upregulated and 90 were downregulated
; 141 GO biological processes were annotated with 234 genes, of which 83 were upregulated and 151 were downregulated
; and 34 GO cellular components were annotated with 221 genes, of which 134 were upregulated and 87 were downregulated
(Table 3 and Supplementary Table S1c).
For example, mtDNA damage has been noted in osteoarthritis along with downregulated
Complexes I, II, and III, and 17 upregulated and 9 downregulated
5B), being upregulated significantly within the first 6 h and then gradually downregulated
to the original level 48 h after stimulation.
GRHL2 overexpression was detected in several cancers; however, in certain subclasses of breast cancer, GRHL2 was downregulated
Ad-siTNF[alpha]BMP-2 directly and indirectly downregulated
TNF-[alpha] and RANKL expression in our experiment.
Conversely, the levels of miR-200b and miR-19b were downregulated
under the same experimental conditions (Dippold et al.
In contrast, other proapoptotic proteins such as nuclear factor-[kappa]B, cytochrome c, apoptosis-inducing factor, and cleaved poly(adenosine diphosphate-ribose) polymerase levels were significantly downregulated
in the COC-treated group when compared with the untreated control group.
Gene expression analysis determined the numbers and types of up-and downregulated
genes in both cultured cells and adipose tissue, with those involved in inflammation being the most significantly upregulated.
perilipin was thought to account for the increased lipolytic action of TNF[alpha] in differentiated adipocytes (Miyoshi et al.
Interestingly, these miRNAs have been found to be overexpressed in AIPC, but downregulated
during androgen-dependent prostate cancers.
Members of the Cyp family of genes split into two separate clusters, some were downregulated
(Figure 3E, H) and others were very markedly upregulated (Figure 3B, H).