down-regulation


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Related to down-regulation: Upregulation, Up-regulation

down-regulation

 [down-reg-u-la´shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. See also up-regulation.

down-reg·u·la·tion

(down-reg'yū-lā'shŭn),
Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors.
References in periodicals archive ?
Reconstitution of ATIP3 inhibits tumor growth, which led to an increase in survival rate in ovarian carcinoma via down-regulation of the ERK/EMT pathway [27].
There were 26(14%) subjects in the 41-50 year age bracket and 16(61.5%) 16/26 of them had down-regulation (p<0.09).
The merit of down-regulation of hspX expression needs to be explored in its possible role to prevent dormancy, allow multiplication of the parasite so that anti-mycobacterial agents used for therapy of tuberculosis can act effectively, thus, eliminating the organisms.
A medium down-regulation of the badh2 gene (-2.66 +- 0.03 fold) was observed in MRQ 50 genotype in ambient condition.
We next studied the effect of FAMLF down-regulation by miR-181b on cell viability.
GBE showed up-regulation for hepatic IRS-1 and down-regulation for PEPCK, however, up-regulation for GLUT-4 and PPAR-a found in muscle.
There also appears to be a programmed down-regulation in the reward pathway of the brain, and some studies have shown that children of obese mothers and children who were born with low birth weights have a higher preference for sweet and high-calorie foods.
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
We conclude that down-regulation of bioenergetics is an important mechanism for the pathological development ...
The up- or down-regulation of p107 can lead to the management of "good (BAT)" or "bad (WAT)" adipose tissue in the human body.
Down-regulation of miR-128 was prevailing in high-grade gliomas and the plasma levels of miR-128 with significant alteration in glioblastoma multiforme (GBM) patients could discriminate glioma from a healthy population with high specificity and sensitivity.
The allowed claims cover use of PV-10 in combination with systemic inhibitors of immune system down-regulation, such as anti-CTLA-4, PD-1 and PD-L1 antibodies, along with enhancers of immune system up-regulation, such as IL-2 and interferon-gamma.