down-regulate


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Related to down-regulate: Up-regulation

down-regulate

to induce a reduction in the level of expression of a gene by genetic means.
References in periodicals archive ?
Sangamo is also developing ZFP-TFs to down-regulate the expression of tau, a protein associated with Alzheimer's disease and other tauopathies.
"Reversing cancer with biochemistry utilizes the pathological targets in cancer to down-regulate these targets, weaken tumor cells' defense, up-regulate the immune system, and increase the ability of the body to reverse the disease," she adds.
For example, hsa-miR-29a down-regulates the expression of HIV Nef protein and interferes with HIV-I replication.
Studies show that lenalidomide and thalidomide down-regulate these growth-promoting cytokines.
What I hope can one day happen (as was demonstrated in work presented at the Conference on Retroviruses and Opportunistic Infections a few years ago, where monkeys with SIV remained healthy despite having high viral loads) is that we can exploit how to down-regulate the ability of the immune system to react to HIV.
A breakdown product of gram-negative bacteria often found in an animal's mouth, endotoxins down-regulate the portion of the immune system that mounts an allergic response.
-2 week high-calorie period up-regulates anabolic hormones, enzyme activities, and receptors without giving the fat-burning catabolic pathways enough time to down-regulate. A subsequent 1?
This suggested that shANRIL transfection could effectively down-regulate ANRIL expression in MKN-45 and SGC-7901 cells.
Building on the pioneering discovery of RNAi, scientists at RXi have harnessed the naturally occurring RNAi process which can be used to "silence" or down-regulate the expression of a specific gene that may be overexpressed in a disease condition.
Among the several biological effects of curcumin, the ability to down-regulate the T cell-mediated process, and in particular the Th22 pathway, may be considered one of the major mechanisms by which Meriva supports skin dysfunction recovery, according to researchers.
In the brain, the tricyclic antidepressants, selective serotonin-reuptake inhibitors (SSRIs) as well as serotonin and noradrenalin-reuptake inhibitors (SNRIs) were shown to down-regulate the N-methyl-n-aspartate (NMDA) glutamate receptors and to potentiate the AMPA glutamate receptors (Novak et al.
The product has also been shown to modulate prostaglandin and leukotriene pathways and down-regulate cytokine gene expression, resulting in reduction of skin inflammation.