dose-response curve


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curve

 [kerv]
a line that is not straight, or that describes part of a circle, especially a line representing varying values in a graph.
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose.
growth curve the curve obtained by plotting increase in size or numbers against the elapsed time.
oxyhemoglobin dissociation curve a graphic curve representing the normal variation in the amount of oxygen that combines with hemoglobin as a function of the partial pressures of oxygen and carbon dioxide. The curve is said to shift to the right when less than a normal amount of oxygen is taken up by the blood at a given Po2, and to shift to the left when more than a normal amount is taken up. Factors influencing the shape of the curve include changes in the blood pH, Pco2, and temperature; the presence of carbon monoxide; alterations in the constituents of the erythrocytes; and certain disease states.
pulse curve sphygmogram.
Spee curve (curve of Spee) the anatomic curvature of the occlusal alignment of teeth, beginning at the tip of the lower canine, following the buccal cusps of the premolars and molars, and continuing to the anterior border of the ramus.
strength-duration curve a graphic representation of the relationship between the intensity of an electric stimulus at the motor point of a muscle and the length of time it must flow to elicit a minimal contraction; see also chronaxie and rheobase. In cardiac pacing it is useful in determining characteristics of a particular pacing electrode and determining the most efficient selection of pacing parameters for an appropriate safety margin.
survival curve a graph of the probability of survival versus time, commonly used to present the results of clinical trials, e.g., a graph of the fraction of patients surviving (until death, relapse, or some other defined endpoint) at each time after a certain therapeutic procedure.

dose-·re·sponse curve

a graph showing the relationship between (for example, dosage of a drug, infectious agent) and the biologic response.

dose-response curve

A graphic representation of the effects that varous doses of an agent–eg, ionizing radiation or a chemotherapeutic agent, have on a given parameter–eg, cell viability, mutation frequency, DNA damage, tumor growth or metastasis or other behavior Therapeutics A graphic representation of the effectiveness or toxicity of a drug vs the dose administered
References in periodicals archive ?
8% of all data were equally well described by both approaches (comparison of coefficients of determination) and 81% were better described by the sigmoidal dose-response curve used for the determination of NtCs.
Fentanyl dose-response curves when inserting the LMA Classic laryngeal mask airway.
Applying these principles, a Frye court could find that the use of a nonmonotonic, non-threshold dose-response curve theory is generally accepted in the relevant scientific community for alleged EDCs because it has been published and subjected to peer-review in the Vandenberg article.
(2012b) suggested that the dose at which the slope of the S-shaped dose-response curve changes the most per unit log-dose, denoted [BMD.sub.T], may serve as a standardized reference point in the low dose-region for in vitro data.
Implementation of a dose-response curve for gamma-radiation in the Portuguese population by use of the chromosomal aberration assay.
In group 1 cumulative dose-response curves of histamine were constructed with varying concentrations(10-8 to10- 3M).11 When maximum response with 10-8 M concentration was obtained the subsequent doses were added without washing the previous dose.
This can also be referred to as a biphasic dose-response curve." Every biologic dose-response curve that I'm aware of is S-shaped, not a straight line.
A dose-response curve for CAF was obtained by plotting the peak area of the retained peak in the CL fractogram against CAF concentration (Fig.
This kind of a U-shaped dose-response curve is not unprecedented, Dr.
Figure 1 is a dose-response curve after 5 years of exposure.
This relationship is best visualized by graphically plotting the level of response--no effect, moderate effect, death--against increasing dosages to create a dose-response curve. Much of toxicology is based on this direct relationship between dose and response and on toxicologists' attempts to identify the particular dose-response curve for human beings and specific chemicals.