Group-2: Dose response
curve was made using cumulatively increasing concentrations of metoclopramide (6-30 ug) on isolated piece of duodenum (n=6) of rabbits21.
"This reward recognizes the research I have conducted in the past few years aiming to understand, using computer simulations, the nature of many experimentally observed nonlinear, including non-monotonic, biological dose response
curves in the low-dose region for a variety of chemicals," said Dr.
data from our previous studies are summarised in the Appendix.
Individual and population-level dose response
. The starting point of this framework is that a conceptual distinction exists between effects on the individual and effects on the population.
Zerenex reportedly met the study's primary endpoint, demonstrating a highly statistically significant dose response
. In addition, key secondary endpoints were also met with high statistical significance.
A clear dose response
was seen between the active treatment groups, with the 1.25% group showing trends toward efficacy.
Data from Cohort 6 showed improved efficacy and a clear dose response
compared to prior cohorts, including a 50% partial response rate, a 50% minimal response rate and 100% disease control rate.
A mathematical model illustrating the dose response
expected for proportional feedback control is provided in Supplemental Material, "Proportional Feedback Control."
The multi-centre, randomised, double-blind, placebo-controlled, dose response
, factorial 12-arm parallel group trial, carried in the UK, assessed 120 patients equally randomised to receive droxidopa alone, carbidopa alone, droxidopa/carbidopa combination therapy or placebo.
"We've also demonstrated a dose response
,' Yu says.
Data from the now complete trial confirm previously reported results showing a single dose of oral 750 mg BCX7353 was well-tolerated and superior to placebo against the majority of efficacy endpoints evaluated in HAE patients suffering an acute attack, and demonstrate a clear dose response
across the three dose levels.
Previously we reported that the rapid effect of BPA on the contractility of female cardiac myocytes is characterized by a nonmonotonic dose response
(Belcher et al.