Cumulative dose response curve
was constructed by plotting increasing concentrations of ranitidine on x-axis and the percent response on y-axis.
The 50% inhibitory concentration (IC50) value was estimated from a dose response curve
The dose response curves
for optimum insertion conditions for the present and our other two previous studies (6,7) were compared for parallelism by comparing the straight lines of best fit to the sigma shaped dose-response curves using the t-test method outlined by Tallarida (13), incorporated into PharmTools Pro software, (McCary Group, Elkins Park, PA, USA).
In this edition of Anaesthesia and Intensive Care, Kim and colleagues use a different study design based on dose response curves
and probit analysis, to study spinal block in patients undergoing total knee replacement arthroplasty (3).
2012) have also collected several hundred examples of nonmonotonic dose response curves
(representing many classes of environmental chemicals) that have been observed in cultured cells, animals, and even human populations, Most important, they reviewed the voluminous endocrine literature on how and why nonlinear responses manifest at different levels of biological complexity, including the combination of competing monotonic responses (such as enhanced cell proliferation and cytotoxicity), the expression of cell-and tissue-specific cofactors and receptors, and receptor down-regulation, desensitization, and competition.
This reward recognizes the research I have conducted in the past few years aiming to understand, using computer simulations, the nature of many experimentally observed nonlinear, including non-monotonic, biological dose response curves
in the low-dose region for a variety of chemicals," said Dr.
Once dose response curves
were established, performance goals were set, and dose-equivalent factors were calculated.
Dose response curves
were generated for 0 - 100 EU/mL endotoxin levels and the T2Endotoxin assay demonstrated a sensitivity of 0.
Most of the extracts shifted the dose response curves
of acetylcholine and histamine to the right in a dose-dependent manner.