Orexinergic neurons were widely distributed in lateral hypothalamus, perifornical area, and dorsomedial hypothalamic nucleus
with their projections widely sent throughout the nervous system like the amygdale, bed nucleus of stria terminalis, and hippocampus.
To verify the proinflammatory effects of visfatin on microglial cells determined by the above in vitro approaches, we additionally evaluated the activation of microglia in the hypothalamic areas such as arcuate nucleus (ARC), ventromedial nucleus of the hypothalamus (VMH), and dorsomedial hypothalamic nucleus
(DMH) after immunostaining with Iba-1, a molecular marker for microglia.
In the dorsomedial hypothalamic nucleus
(DM) (Figure 5), as in VTA, one-way nonparametric ANOVA revealed a significant effect of treatment on P-CREB staining ([chi square] = 22.3, df = 8, P = 0.004).
Singewald, "Inhibitory function of the dorsomedial hypothalamic nucleus
on the hypothalamicpituary-adrenal axis response to an emotional stressor but not immune challenge," Journal of Neuroendocrinology, vol.
Effect of chemical stimulation of the dorsomedial hypothalamic nucleus
on blood plasma glucose, triglycerides, and free fatty acids in rats.
When Yanagisawa's team examined gene activity in these animals' brains, they found that genes in a region called the dorsomedial hypothalamic nucleus
(DMH) cycled on and off rhythmically during the day.