dorsal raphe nucleus


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dorsal raphe nucleus

A midbrain nucleus that lies in the midline in the tegmentum, below the periaqueductal gray. It sends serotonergic axons to the striatum via the medial forebrain bundle, and it receives axons from the interpeduncular nucleus.
See: raphe nucleus
See also: nucleus
References in periodicals archive ?
McDevitt and colleagues [57] found that 5-HT1B over-expression in the caudal dorsal raphe nucleus reduced expression of conditioned fear and depression-like behavior; they also found that systemic administration of the 5-HT1B agonist CP-94,253 reduced freezing.
Dorsal raphe nucleus serotonergic neurons innervate the rostral ventrolateral medulla in rat.
Anatomically, much research has focused on the locus ceruleus, the hypothalamus, and the dorsal raphe nucleus. The hypothalamus plays a role in the onset and maintenance of sleep while the locus ceruleus and the dorsal raphe nucleus play a role in the onset and maintenance of REM sleep.