Although sleep attacks were initially described in patients receiving pramipexole and ropinirole, it is clear that sedative effects and USE can be seen with any dopaminergic agents
, including levodopa, (68-71) and that these effects are dose related, occurring with greater frequency in patients taking relatively high doses.
Effects of the dopaminergic agent
and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and [D.
When augmentation occurs, your usual dose of a dopaminergic agent
(most often seen with Sinemet) will allow you to obtain relief from your symptoms so that you will be able to sleep at night, but the sensations, the need to move, and the restlessness will develop (frequently with an increased intensity) earlier in the day (during the afternoon or even during the morning).
Improve management of motor symptoms with dopaminergic agents
sup], More recent studies, however, showed that latencies to Hoehn and Yahr (HY) Stage IV and V could last for up to 40 years [sup], attributing to the advent of effective symptomatic therapies with dopaminergic agents
, seemingly delaying the progression of disabilities in PD.
The treatment provides an alternative for patients who take various medications, including sleep medications, dopaminergic agents
, such as amphetamines, anticonvulsants, such as gabapentin (Neurontin), opioids, such as hydrocodone (Vicodin), or muscle relaxants, such as carisoprodol (Soma), or who must get up in the night and move their legs to relieve symptoms, thus losing sleep.
The effectiveness of dopaminergic agents
in the treatment of RLS was described as early as 1982 (Thorpy, 2007).
If increasing iron stores, avoidance of exacerbating factors and regular exercise do not improve WED symptoms, prescription medications such as gabapentin, clonazepam, narcotics and dopaminergic agents
are effective in treating the disorder.
The effect of local and systemic application of dopaminergic agents
on tail flick latency in the rat.
This would mean optimizing dopaminergic agents
or using a long-acting levodopa or a catechol-O-methyltransferase (COMT) inhibitor.
The first-line drugs for RLS are dopaminergic agents
, which are effective in low to moderate doses.
PHOENIX -- Sometimes, treating restless legs syndrome with dopaminergic agents
can make the problem worse.