Dopamine receptor antagonists


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Dopamine receptor antagonists (DAs)

The older class of antipsychotic medications, also called neuroleptics. These primarily block the site on nerve cells that normally receive the brain chemical dopamine.
Mentioned in: Schizophrenia
References in periodicals archive ?
Therefore, the D1-like dopamine receptor antagonist SCH 23390 can block a short-term morphine-induced increase in c-fos expression in the nucleus accumbens and caudate putamen [21].
In a study by Daunais & McGinty (1996), selective D1 or D2 dopamine receptor antagonists were used to investigate the transynaptic regulation of mRNAs coding for the opioid peptide, preprodynorphin, and the nuclear transcription factor, zif/268 after an acute cocaine binge.
Both classes of drugs are dopamine receptor antagonists that work by blocking the action of naturally occurring dopamine in the brain.