DRD3

(redirected from Dopamine D3 receptor)

DRD3

A gene on chromosome 3q13.3 that encodes G protein-coupled dopamine receptor D3, which inhibits adenylyl cyclase. D3 dopamine  receptor localises to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions.
Molecular pathology Genetic variants of DRD3 cause essential tremor hereditary type 1 .
References in periodicals archive ?
Furthermore, L-THP attenuated the decrease in dopamine D3 receptor mRNA expression levels in the striatum of the rats induced by METH.
In addition, I tested if L-THP has a role in modulating METH-induced dopamine D3 receptor expression changes in the striatum of rat.
Semiquantitative RT-PCR of dopamine D3 receptor in the striatum
Effect of L-THP on METH-induced dopamine D3 receptor mRNA expression level changes
Using brain scans and a novel chemical probe developed in CAMH's Research Imaging Centre, CAMH scientists found that the probe had high levels of binding to the dopamine D3 receptor in some people with methamphetamine addiction, compared with those who had no addiction.
The new chemical probe developed at CAMH, called 11C-(+)-PHNO, binds to dopamine D3 receptors.
NewsScan #65 includes summaries of eight NIDA-funded scientific studies on a variety of topics, including school responses to suspicionless random drug testing, effects of targeting the brain's dopamine D3 receptor, how glutamate transmissions eliminates cocaine-induced place preference in rats, how men with AAS dependence have prevalence of opioid dependence, benzotropine analogs reduces cocaine self-administration in rats, new database for addiction-related genes, injection drug users in Mexico have latent TB infection and how drug combinations contribute to HIV risk in gay/bisexual men.
ABT-925 promises to be a potent and selective dopamine D3 receptor antagonist, currently in early Phase II clinical trials for schizophrenia.
The dopamine D3 receptor that is specifically targeted by ropinirole may be pivotal to many autonomically controlled functions, including sleep, vasomotor and cardiovascular function, gastric acidity, bowel motility, and temperature regulation, Dr.
The selective dopamine D3 receptor antagonist SB-277011 A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.
Abbott has taken a unique approach to schizophrenia research, targeting efforts on finding compounds that selectively bind to the dopamine D3 receptor to target the positive, negative and cognitive symptoms of the disease while showing favorable tolerability.
In the study, a dopamine D3 receptor agonist, known as 7-hydroxy-dipropyl- aminotetralin (7-OH-DPAT), was combined with CAP in a proprietary formulation prepared by scientists at BioSante's research center in Smyrna, Ga.