DRD3

(redirected from Dopamine D3 receptor)

DRD3

A gene on chromosome 3q13.3 that encodes G protein-coupled dopamine receptor D3, which inhibits adenylyl cyclase. D3 dopamine  receptor localises to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions.
Molecular pathology Genetic variants of DRD3 cause essential tremor hereditary type 1 .
References in periodicals archive ?
Di Ciano, "Recent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug development," Frontiers in Pharmacology, vol.
Dopamine D3 receptor antagonists have been shown to work in rodent models of drug abuse (21) but have not yet been tested in humans.
The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.
Furthermore, L-THP attenuated the decrease in dopamine D3 receptor mRNA expression levels in the striatum of the rats induced by METH.
Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands.
Muhlbauer et al., "Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes," Laboratory Investigation, vol.
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA.
Using brain scans and a novel chemical probe developed in CAMH's Research Imaging Centre, CAMH scientists found that the probe had high levels of binding to the dopamine D3 receptor in some people with methamphetamine addiction, compared with those who had no addiction.
NewsScan #65 includes summaries of eight NIDA-funded scientific studies on a variety of topics, including school responses to suspicionless random drug testing, effects of targeting the brain's dopamine D3 receptor, how glutamate transmissions eliminates cocaine-induced place preference in rats, how men with AAS dependence have prevalence of opioid dependence, benzotropine analogs reduces cocaine self-administration in rats, new database for addiction-related genes, injection drug users in Mexico have latent TB infection and how drug combinations contribute to HIV risk in gay/bisexual men.
The dopamine D3 receptor that is specifically targeted by ropinirole may be pivotal to many autonomically controlled functions, including sleep, vasomotor and cardiovascular function, gastric acidity, bowel motility, and temperature regulation, Dr.
The selective dopamine D3 receptor antagonist SB-277011 A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.
Cariprazine has higher binding affinity for dopamine D3 receptors (Ki 0.085 nM) than for D2L receptors (Ki 0.49 nM) and D2S receptors (Ki 0.69 nM).