DRD3

(redirected from Dopamine D3 receptor)

DRD3

A gene on chromosome 3q13.3 that encodes G protein-coupled dopamine receptor D3, which inhibits adenylyl cyclase. D3 dopamine  receptor localises to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions.
Molecular pathology Genetic variants of DRD3 cause essential tremor hereditary type 1 .
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Di Ciano, "Recent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug development," Frontiers in Pharmacology, vol.
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
Dopamine D3 receptor antagonists have been shown to work in rodent models of drug abuse (21) but have not yet been tested in humans.
Developing treatments for stimulant abuse: a brief overview
The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.
Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280
Furthermore, L-THP attenuated the decrease in dopamine D3 receptor mRNA expression levels in the striatum of the rats induced by METH.
L-Tetrahydropalmatine inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal activity and dopamine D3 receptor expression
Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands.
Secondary metabolismin in Annonaceae: potencial source of drugs/Metabolismo secundario em annonacea: fonte potencial de drogas
Muhlbauer et al., "Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes," Laboratory Investigation, vol.
Signaling pathways involved in renal oxidative injury: Role of the Vasoactive Peptides and the renal dopaminergic System
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA.
Advances in genetic studies of substance abuse in China
Using brain scans and a novel chemical probe developed in CAMH's Research Imaging Centre, CAMH scientists found that the probe had high levels of binding to the dopamine D3 receptor in some people with methamphetamine addiction, compared with those who had no addiction.
Potential target for anti-craving medications identified
NewsScan #65 includes summaries of eight NIDA-funded scientific studies on a variety of topics, including school responses to suspicionless random drug testing, effects of targeting the brain's dopamine D3 receptor, how glutamate transmissions eliminates cocaine-induced place preference in rats, how men with AAS dependence have prevalence of opioid dependence, benzotropine analogs reduces cocaine self-administration in rats, new database for addiction-related genes, injection drug users in Mexico have latent TB infection and how drug combinations contribute to HIV risk in gay/bisexual men.
NIDA News Scan #65
The dopamine D3 receptor that is specifically targeted by ropinirole may be pivotal to many autonomically controlled functions, including sleep, vasomotor and cardiovascular function, gastric acidity, bowel motility, and temperature regulation, Dr.
Ropinirole may resolve refractory fibromyalgia: unblinded study. (Rx)
The selective dopamine D3 receptor antagonist SB-277011 A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.
Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release
Cariprazine has higher binding affinity for dopamine D3 receptors (Ki 0.085 nM) than for D2L receptors (Ki 0.49 nM) and D2S receptors (Ki 0.69 nM).
Cariprazine for schizophrenia and bipolar I disorder: as a dopamine D3-preferring D3/D2 partial agonist, cariprazine offers an alternative to antipsychotics that preferentially modulate D2 receptors

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