DRD3

(redirected from Dopamine D3 receptor)

DRD3

A gene on chromosome 3q13.3 that encodes G protein-coupled dopamine receptor D3, which inhibits adenylyl cyclase. D3 dopamine  receptor localises to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions.
Molecular pathology Genetic variants of DRD3 cause essential tremor hereditary type 1 .
References in periodicals archive ?
Dopamine D3 receptor antagonists have been shown to work in rodent models of drug abuse (21) but have not yet been tested in humans.
The selective dopamine D3 receptor antagonist SB-277011A significantly accelerates extinction to environmental cues associated with cocaineinduced place preference in male Sprague-Dawley rats.
The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS.
Furthermore, L-THP attenuated the decrease in dopamine D3 receptor mRNA expression levels in the striatum of the rats induced by METH.
Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands.
190] In China, Li and colleagues [191] reported that dopamine D3 receptor knockout mice had pronounced hypoalgesia, decreased morphine-induced tolerance, and attenuated withdrawal symptoms; this helped to clarify the interaction between morphine-induced antinociceptive tolerance and D3 receptors.
Using brain scans and a novel chemical probe developed in CAMH's Research Imaging Centre, CAMH scientists found that the probe had high levels of binding to the dopamine D3 receptor in some people with methamphetamine addiction, compared with those who had no addiction.
NewsScan #65 includes summaries of eight NIDA-funded scientific studies on a variety of topics, including school responses to suspicionless random drug testing, effects of targeting the brain's dopamine D3 receptor, how glutamate transmissions eliminates cocaine-induced place preference in rats, how men with AAS dependence have prevalence of opioid dependence, benzotropine analogs reduces cocaine self-administration in rats, new database for addiction-related genes, injection drug users in Mexico have latent TB infection and how drug combinations contribute to HIV risk in gay/bisexual men.
The dopamine D3 receptor that is specifically targeted by ropinirole may be pivotal to many autonomically controlled functions, including sleep, vasomotor and cardiovascular function, gastric acidity, bowel motility, and temperature regulation, Dr.
The selective dopamine D3 receptor antagonist SB-277011 A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.
The study, Dopamine D3 receptors modulate the ability of win-paired cues to increase risky choice in a rat gambling task, was published in the Journal of Neuroscience today .