DRD2

(redirected from Dopamine D2 receptor)

DRD2

A gene on chromosome 11q23 that encodes G protein-coupled dopamine receptor D2, which inhibits adenylyl cyclase.

Molecular pathology
Defects in DRD2 are associated with myoclonic dystonia.
References in periodicals archive ?
The most potent antipsychotic dopamine D2 receptor antagonists are risperidone and paliperidone, followed by haloperidol and most other first-generation antipsychotics.
This feel-good effect is caused by the neurotransmitter dopamine -- tempting foods stimulate the reward centre in the brain where the dopamine D2 receptor is located.
Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland.
In the early 1990s, a unique gene variant, the A1 allele in dopamine D2 receptor gene, was found in patients with alcoholism.
The researchers found that the dopamine D2 receptor gene (D2R) significantly influences lifespan, body weight and locomotor activity, but only when combined with an enriched environment that included social interaction, sensory and cognitive stimulation and, most critically, exercise.
Aripiprazole is a unique antipsychotic drug because it causes a partial agonism at the dopamine D2 receptor (10).
Many drugs have been reported to induce dystonic reactions as a result of dopamine D2 receptor blockage; it has been emphasized by various studies that the properties and dose of a drug and an individual's sensitivity to that drug affect the emergence of dystonic reactions.
Association of the TaqI A polymorphism of the dopamine D2 receptor gene with predisposition to neuroleptic malignant syndrome.
Dopamine D2 receptor promoter region and COMT gene (in Chinese).
They detected antibodies to the dopamine D2 receptor or the N-methyl-D-aspartate (NMDA) glutamate receptor in a subgroup of children experiencing their first episode of psychosis, but no such antibodies in healthy children.
Putative targeting of dopamine D2 receptor function In reward deficiency syndrome (RDS) by Synaptamine Complex' Variant (KB220): clinical trial showing anti-anxiety effects.
The team found that depending on the arrangement of the dopamine D2 receptor in the brain, the mechanism of the action also changes.