Donovan bodies

Don·o·van bod·ies

(don'ŏ-văn),
clusters of blue or black staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Calymmatobacterium granulomatis.

Don·o·van bod·ies

(don'ŏ-văn bod'ēz)
Clusters of blue- or black-staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Klebsiella (Calymmatobacterium granulomatis).

Donovan bodies

The microscopic appearance caused in cell scrapings from the genital region in the tropical sexually transmitted disease GRANULOMA INGUINALE. The Donovan bodies are seen in stained mononuclear cells and are caused by the infecting agent Donovania granulomatis . (Lt Col. Charles Donovan, 1863–1951, Irish physican).

Donovan bodies

Rod-shaped oval organisms found in tissue samples from patients with granuloma inguinale. Donovan bodies appear deep purple when stained with Wright's stain.
Mentioned in: Granuloma Inguinale

Donovan,

Charles, English surgeon, 1863-1951.
Donovan bodies - clusters of blue or black staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Calymmatobacterium granulomatis.
Leishman-Donovan body - see under Leishman
References in periodicals archive ?
During this time period, 11 percent and 16 percent for men and women, respectively, of all ulcers in this region were found to have Donovan bodies. After this epidemic ended, K.
granulomatis was identified by the presence of Donovan bodies, and antibiotic treatment with azithromycin and trimoxazole failed.
A smear was made from the tissue, and basophilic bipolar Donovan bodies were seen in the macrophages.
The presence of Donovan bodies confirmed the pathogen, and streptomycin was used to successfully treat her, with the patient showing improvement after a month.
While the etiological agent of donovanosis is a gram-negative coccobacilli, the best way to differentiate this pathogen from the other causes of genital lesions is through histological evaluation whereby Donovan bodies are seen within mononuclear cells and the characteristic safety pin appearance is identified.
Evaluation date of suspected cases of kala-azar and response to treatment (SAG) Parameters Cases (n=6) 1 2 3 4 Fever (> 2 wk) Present Present Present Present Spleen Palpable Palpable Palpable Palpable Liver Palpable Palpable Not Palpable Palpable Aldehyde test +ve +ve +ve -ve LD bodies ND +ve +ve ND rK39 ND ND +ve ND Malaria parasite -ve -ve -ve -ve Treatment response Cured Cured Cured Cured 5 6 Fever (> 2 wk) Present Present Spleen Palpable Palpable Liver Palpable Palpable Aldehyde test +ve +ve LD bodies ND ND rK39 +ve ND Malaria parasite -ve -ve Treatment response Cured Cured ND, not done; LD bodies, Leishman Donovan bodies
A clinical hypothesis can be confirmed in the laboratory by the discovery of Donovan bodies in the fragment of the lesion, using cytodiagnosis or pathoanatomical exams.
Remaining techniques will be used in cases which have a limited number of Donovan bodies, such as happens when lesions have a shortened period of evolution or in cases in which patients previously used antibiotics [20,25,36].
The Cultivation from Granuloma Inguinale of Microorganism Having the Characteristic of Donovan Bodies in Yolk Sac of Chick Embryos.
Mycodot, PCR for mycobacterial DNA, slit skin and Leishman- Donovan bodies (LD bodies) smears were negative.